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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 203-963-7 | CAS number: 112-36-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 50.05 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 25
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 1 251.23 mg/m³
- Explanation for the modification of the dose descriptor starting point:
The dose descriptor was corrected for exposure time difference and difference in respiratory volume: NOAEC corrected=2.49 x 6/8 x 6.7/10=1251.225 mg/m3
- AF for dose response relationship:
- 1
- Justification:
- The dose descriptor is a NOAEL
- AF for differences in duration of exposure:
- 2
- Justification:
- There is minimal difference between the effects following subacute (up to 28 days) and subchronic (up to 90 days) exposure to glycol ethers, either in qualitative or in quantitative terms (ECETOC TR95, 2005). Therefore a factor of 2 is justified for the duration extrapolation factor (subacute to chronic).
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Not applicable as inhalation DNEL
- AF for other interspecies differences:
- 2.5
- Justification:
- There are no data for DEGDEE to quantify other differences between animals and humans that could affect interspecies extrapolation. On this basis a default factor of 2.5 to account for other species differences will also be applied.
- AF for intraspecies differences:
- 5
- Justification:
- There are no data to quantify variability in susceptibility to the effects of long-term exposure to DEGDEE in the human population. The default factor of 5 for workers will therefore be used to take account of intraspecies differences.
- AF for the quality of the whole database:
- 1
- Justification:
- The key study was part of a series of animal studies conducted to methods equivalent to modern regulatory standards. On this basis the quality of the database is not considered to contribute uncertainty and it is therefore not necessary to apply an additional factor.
- AF for remaining uncertainties:
- 1
- Justification:
- No other uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3.43 mg/kg bw/day
- Most sensitive endpoint:
- developmental toxicity / teratogenicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 87.5
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 300 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
There is no data which indicates that the bioavailability or systemic absorbtion of DEGDEE is greater by the dermal route than by the oral route ; on this basis the NOEL from the oral study is used as the starting point for the dermal DNEL, without modification.
- AF for dose response relationship:
- 1
- Justification:
- The dose descriptor starting point is a NOAEL
- AF for differences in duration of exposure:
- 1
- Justification:
- The dose descriptor was obtained from a developmental study in the mouse. AF for exposure duration is not necessary since the experimental exposure covers adequately the pregnancy of the mouse.
- AF for interspecies differences (allometric scaling):
- 7
- Justification:
- Allometric scaling factor for the mouse
- AF for other interspecies differences:
- 2.5
- Justification:
- There are no data for DEGDEE to quantify other differences between animals and humans that could affect interspecies extrapolation. On this basis a default factor of 2.5 to account for other species differences will also be applied.
- AF for intraspecies differences:
- 5
- Justification:
- There are no data to quantify variability in susceptibility to the effects of long-term exposure to DEGDEE in the human population. The default factor of 5 for workers will therefore be used to take account of intraspecies differences.
- AF for the quality of the whole database:
- 1
- Justification:
- The key study was part of a series of animal studies conducted to methods equivalent to modern regulatory standards. On this basis the quality of the database is not considered to contribute uncertainty and it is therefore not necessary to apply an additional factor.
- AF for remaining uncertainties:
- 1
- Justification:
- No other uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
The guidance on dose/concentration response regarding human health (section R8.1.2.5 of chapter R.8 of the Guidance on Information Requirements and Chemical Safety Assessment) indicates that acute DNELs do not need to be calculated for substances that are not classified for an acute toxicity hazard. As this substance is not classified for acute toxicity hazards, no acute DNELs need to be calculated.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 5.96 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 50
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 297.92 mg/m³
- Explanation for the modification of the dose descriptor starting point:
The dose descriptor was corrected for exposure time difference and difference in respiratory volume: NOAEC corrected=2.49 x [(6x5)/(24x7)]x 6.7/10= 297.92 mg/m3
- AF for dose response relationship:
- 1
- Justification:
- The dose descriptor is a NOAEL
- AF for differences in duration of exposure:
- 2
- Justification:
- There is minimal difference between the effects following subacute (up to 28 days) and subchronic (up to 90 days) exposure to glycol ethers, either in qualitative or in quantitative terms (ECETOC TR95, 2005). Therefore a factor of 2 is justified for the duration extrapolation factor (subacute to chronic).
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Not applicable as inhalation DNEL
- AF for other interspecies differences:
- 2.5
- Justification:
- There are no data for DEGDEE to quantify other differences between animals and humans that could affect interspecies extrapolation. On this basis a default factor of 2.5 to account for other species differences will also be applied.
- AF for intraspecies differences:
- 10
- Justification:
- There are no data to quantify variability in susceptibility to the effects of long-term exposure to DEGDEE in the human population. The default factor of 10 for the general population will therefore be used to take account of intraspecies differences.
- AF for the quality of the whole database:
- 1
- Justification:
- The key study was part of a series of animal studies conducted to methods equivalent to modern regulatory standards. On this basis the quality of the database is not considered to contribute uncertainty and it is therefore not necessary to apply an additional factor.
- AF for remaining uncertainties:
- 1
- Justification:
- No other uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.71 mg/kg bw/day
- Most sensitive endpoint:
- developmental toxicity / teratogenicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 175
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 300 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
There is no data which indicates that the bioavailability or systemic absorbtion of DEGDEE is greater by the dermal route than by the oral route ; on this basis the NOEL from the oral study is used as the starting point for the dermal DNEL, without modification.
- AF for dose response relationship:
- 1
- Justification:
- The dose descriptor starting point is a NOAEL
- AF for differences in duration of exposure:
- 1
- Justification:
- The dose descriptor was obtained from a developmental study in the mouse. AF for exposure duration is not necessary since the experimental exposure covers adequately the pregnancy of the mouse.
- AF for interspecies differences (allometric scaling):
- 7
- Justification:
- Allometric scaling factor for the mouse
- AF for other interspecies differences:
- 2.5
- Justification:
- There are no data for DEGDEE to quantify other differences between animals and humans that could affect interspecies extrapolation. On this basis a default factor of 2.5 to account for other species differences will also be applied.
- AF for intraspecies differences:
- 10
- Justification:
- There are no data to quantify variability in susceptibility to the effects of long-term exposure to DEGDEE in the human population. The default factor of 10 for the general population will therefore be used to take account of intraspecies differences.
- AF for the quality of the whole database:
- 1
- Justification:
- The key study was part of a series of animal studies conducted to methods equivalent to modern regulatory standards. On this basis the quality of the database is not considered to contribute uncertainty and it is therefore not necessary to apply an additional factor.
- AF for remaining uncertainties:
- 1
- Justification:
- No other uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.71 mg/kg bw/day
- Most sensitive endpoint:
- developmental toxicity / teratogenicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 175
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 300 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Not applicable
- AF for dose response relationship:
- 1
- Justification:
- The dose descriptor starting point is a NOAEL
- AF for differences in duration of exposure:
- 1
- Justification:
- The dose descriptor was obtained from a developmental study in the mouse. AF for exposure duration is not necessary since the experimental exposure covers adequately the pregnancy of the mouse.
- AF for interspecies differences (allometric scaling):
- 7
- Justification:
- Allometric scaling factor for the mouse
- AF for other interspecies differences:
- 2.5
- Justification:
- There are no data for DEGDEE to quantify other differences between animals and humans that could affect interspecies extrapolation. On this basis a default factor of 2.5 to account for other species differences will also be applied.
- AF for intraspecies differences:
- 10
- Justification:
- There are no data to quantify variability in susceptibility to the effects of long-term exposure to DEGDEE in the human population. The default factor of 10 for the general population will therefore be used to take account of intraspecies differences.
- AF for the quality of the whole database:
- 1
- Justification:
- The key study was part of a series of animal studies conducted to methods equivalent to modern regulatory standards. On this basis the quality of the database is not considered to contribute uncertainty and it is therefore not necessary to apply an additional factor.
- AF for remaining uncertainties:
- 1
- Justification:
- No other uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
The guidance on dose/concentration response regarding human health (section R8.1.2.5 of chapter R.8 of the Guidance on Information Requirements and Chemical Safety Assessment) indicates that acute DNELs do not need to be calculated for substances that are not classified for an acute toxicity hazard. As this substance is not classified for acute toxicity hazards, no acute DNELs need to be calculated.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.