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Diss Factsheets
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EC number: 939-180-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Publication describing two case studies.
Data source
Reference
- Reference Type:
- publication
- Title:
- Allergic contact dermatitis from aziridine crosslinker cx100
- Author:
- Ibbotson SH, Lawrence CM
- Year:
- 1 994
- Bibliographic source:
- Contact Dermatitis, 30, 306-307.
Materials and methods
- Study type:
- clinical case study
- Endpoint addressed:
- skin sensitisation
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-({3-[2,2-bis({[3-(2-methylaziridin-1-yl)propanoyl]oxy}methyl)butoxy]-3-oxopropoxy}methyl)-2-({[3-(2-methylaziridin-1-yl)propanoyl]oxy}methyl)butyl 3-(2-methylaziridin-1-yl)propanoate; 2-ethyl-6-(2-methylaziridin-1-yl)-2-({[3-(2-methylaziridin-1-yl)propanoyl]oxy}methyl)-4-oxohexyl 3-(2-methylaziridin-1-yl)propanoate
- EC Number:
- 939-180-9
- Molecular formula:
- Not relevant - Multiconstituent substance
- IUPAC Name:
- 2-({3-[2,2-bis({[3-(2-methylaziridin-1-yl)propanoyl]oxy}methyl)butoxy]-3-oxopropoxy}methyl)-2-({[3-(2-methylaziridin-1-yl)propanoyl]oxy}methyl)butyl 3-(2-methylaziridin-1-yl)propanoate; 2-ethyl-6-(2-methylaziridin-1-yl)-2-({[3-(2-methylaziridin-1-yl)propanoyl]oxy}methyl)-4-oxohexyl 3-(2-methylaziridin-1-yl)propanoate
Constituent 1
Results and discussion
- Results of examinations:
- Contact dermatitis due to occupational exposure to adhesives.
Any other information on results incl. tables
15 Printers working in a factory that printed self-adhesive labels, showed 2 cases of skin sensitisation:
Case no. 1
A 43 -y old man working in a factory that printed self-adhesive labels developed rash on his face, arms and body, seven months after the onset of his current work (with 27 years working as water-based printer). The rash improved whilst off work, but recurred within 2 days of return. Examination revealed a severe acute, vesicular eczema of the dorsum and palms of the hands, fingers, head and neck.
Case no.2
A 57 -y old man working in a factory that printed self-adhesive labels developed a rash, five months after the onset of his current work (worked as a printer all his adult life). The rash improved whilst he was off work. On examination eczema of the upper and lower arms, hands, fingers, trunk, head and neck was evident.
Both had no history of atopy or skin disorder and were receiving no medication.
Patch testing was performed on the cases. Case no. 1 reacted to thiuram (1%), while both cases gave positive reactions to crosslinker cx100 (0.1%) at 3 days.
Strict avoidance of direct skin contact will be required to prevent further allergic contact dermatitis.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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