Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 941-224-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1957
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study non-GLP with limited data on study design, however the study was conducted to state of the art methods at that time period. The study is therefore considered adequate, reliable and relevant.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 957
- Report date:
- 1957
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- trisodium 1,4-dioxo-1,4-bis(pentyloxy)butane-2-sulfonate pentane-1-sulfonate pentane-2-sulfonate
- EC Number:
- 941-224-7
- Molecular formula:
- C14H25O7S.Na
- IUPAC Name:
- trisodium 1,4-dioxo-1,4-bis(pentyloxy)butane-2-sulfonate pentane-1-sulfonate pentane-2-sulfonate
- Test material form:
- other: waxy solid
- Details on test material:
- Test material
- Name of test material (as cited in study report): Aerosol AY; sodium diamylsulfosuccinate
- Physical state: White, waxy solid
- Analytical purity: >97%
- Impurities (identity and concentrations): See confidential details
- Composition of test material, percentage of components: See confidential details
- Isomers composition: Not provided
- Purity test date: Not provided
- Lot/batch No.: SPS 900A-MH
- Expiration date of the lot/batch: Not provided
- Stability under test conditions: Not provided
- Storage condition of test material: Not provided
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: albino
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Not provided
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: Aerosol AY was moistened with sufficient water to form a paste
- Details on dermal exposure:
- TEST SITE
- Area of exposure: closely clipped skin of the abdomen
- Type of wrap if used: a cuff of polyethylene film which encircled the trunk of the animal
REMOVAL OF TEST SUBSTANCE
- Washing (if done):
- Time after start of exposure:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2.5 g/kg, 5 g/kg and 10 g/kg
- For solids, paste formed: yes
VEHICLE
- Amount(s) applied (volume or weight with unit): The dose was moistened with sufficient water to form a paste. - Duration of exposure:
- 24 hours
- Doses:
- dosages of 2.5g/kg, 5 g/kg and 10 g/kg ; Aerosol AY was moistened with sufficient water to form a paste.
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Two out of five rabbits died at a dosage of 10 g/kg and one out of five succumbed at 5 g/kg.
- Clinical signs:
- other: Moderate to severe erythema and edema were present in all cases at the end of the exposure period. The edema was greatly reduced by the second day after dosing, and has subsided almost completely by the third day. Erythema persisted to a slight degree a d
- Other findings:
- Moderate to severe erythema and edema were present in all cases at the end of the exposure period. The edema was greatly reduced by the second day after dosing, and has subsided almost completely by the third day. Erythema persisted to a slight degree a day or two longer.
Apart from varying degrees of depression, most animals gave no evidence of systemic toxicity on the day following that of application of the dose. On the second day, however, one animal of the 10 g/kg group exhibited extreme depression and apparent loss of control of the hind legs which were fully extended anteriorly. Altough the animal could hold his head erect, it refused or was unable to attempt movement when placed on the floor. This condition is believed to have been the result of some incidental traumatic injury rather than a consequence of the dose. The animal died on the fourth day. There was another death in the 10 g/kg group, this on the sixth day, and a death at the 5 g/kg level on the sixth day. An LD50 of the product cannot be calculated from these results, although it is certainly greater than 2.5 g/kg. Survivors were observed for a total of seven days after that of the dose, and were then sacrificed. No significant pathology was find by gross autopsy.
Any other information on results incl. tables
Table 1: Aerosol AY: Single Doses to Male Albino Rabbits by Skin Application. Product Administered as an Aqueous Paste Under Polyethylene Film for 24 Hours.
Animal Number |
Body Weight in Grams |
Weight Change in 7 Days |
Dosages in g/kg |
Dose in Grams |
Days to Death |
H 745 |
3075 |
-44 |
10.0 |
30.8 |
S |
H 746 |
3250 |
-645 |
10.0 |
32.5 |
S |
H 747 |
3312 |
- |
10.0 |
33.1 |
6 |
H 748 |
3281 |
- |
10.0 |
32.8 |
4 |
H 749 |
3301 |
-583 |
10.0 |
33.0 |
S |
|
|
|
|
|
|
H 794 |
3203 |
-107 |
5.0 |
16.1 |
S |
H 795 |
3383 |
-245 |
5.0 |
16.9 |
S |
H 797 |
3668 |
-636 |
5.0 |
18.3 |
S |
H 798 |
3625 |
- |
5.0 |
18.1 |
6 |
H 799 |
3802 |
-390 |
5.0 |
19.0 |
S |
|
|
|
|
|
|
H 804 |
3000 |
-532 |
2.5 |
7.5 |
S |
H 805 |
3520 |
-331 |
2.5 |
8.8 |
S |
H 806 |
3270 |
-257 |
2.5 |
8.2 |
S |
H 807 |
3675 |
-199 |
2.5 |
9.2 |
S |
H 808 |
3500 |
-386 |
2.5 |
8.8 |
S |
S= Survived
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Application of dosages of 2.5 g/kg to 10 g/kg as an aqueous paste to the clipped skin of rabbits for 24 hours led to moderate to severe erythema and edema which persisted for three to four days. Two out of five rabbits died at a dosage of 10 g/kg and one out of five succumbed at 5 g/kg.
LD50 > 2500 mg/kg bw. - Executive summary:
Three groups of male albino rabbits, 5 animals per group, received single applications of the test item on the closely-clipped skin of the abdomen at dosages of 2.5 g/kg, 5 g/kg and 10 g active ingredient/kg bw, respectively.
The dose was moistened with sufficient water to form a paste, and retained in contact with the skin for 24 hours by means of a cuff of polyethylene film which was encircled the trunk of the animal. At the end of the period of exposure, the cuff and any excess of the dose were removed, and the skin examined for primary irritation.
Moderate to severe erythema and edema were present in all cases at the end of the exposure period. The edema was greatly reduced by the second day after dosing, and has subsided almost completely by the third day. Erythema persisted to a slight degree a day or two longer.
Apart from varying degrees of depression, most animals gave no evidence of systemic toxicity on the day following that of application of the dose. On the second day, however, one animal of the 10 g/kg group exhibited extreme depression and apparent loss of control of the hind legs which were fully extended anteriorly. Although the animal could hold his head erect, he refused or was unable to attempt movement when placed on the floor. This condition is believed to have been the result of some incidental traumatic injury rather than a consequence of the dose. The animal died on the fourth day. There was another death in the 10 g/kg group, this on the sixth day, and a death at the 5 g/kg level on the sixth day. An LD50 of the product cannot be calculated from these results, although it is certainly greater than 2.5 g/kg. Survivors were observed for a total of seven days after that of the dose, and were than sacrificed. No significant pathology was find by gross autopsy.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.