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EC number: 609-724-7 | CAS number: 39605-45-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Jul 1990 - Feb 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- 1987
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.1100 (Acute Dermal Toxicity)
- Version / remarks:
- 1985
- Deviations:
- no
- GLP compliance:
- yes
- Limit test:
- yes
Test material
- Reference substance name:
- Terbuthylazine
- EC Number:
- 227-637-9
- EC Name:
- Terbuthylazine
- Cas Number:
- 5915-41-3
- Molecular formula:
- C9H16ClN5
- IUPAC Name:
- N-tert-butyl-6-chloro-N'-ethyl-1,3,5-triazine-2,4-diamine
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Appearance: white powder
- Storage condition of test material: room temperature in the dark
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: OFA.SD. (IOPS Caw.)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Iffa-Crédo, France
- Females nulliparous and non-pregnant: yes
- Age at study initiation: 6-8 weeks
- Weight at study initiation: 209-245 g
- Housing: single
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21-25
- Humidity (%): 34-90
- Air changes (per hr): 8
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- water
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 10% of the total body surface
- % coverage: 100
- Type of wrap: perforated adhesive band (Peloplast) 10 cm wide, applied onto an elastic crepe bandage (Creplux / Molinier)
REMOVAL OF TEST SUBSTANCE
- Washing: yes, using lukewarm water
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount applied (volume or weight with unit): 76.46% (w/v) in the vehicle
- For solids, paste formed: yes
- Preparation: performed 1.5 h at meximum before administration
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg equivalent to 2616 ml/kg of the test article as paste at 76.46% (w/v) in purified water.
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 15 min, 1, 2, and 4 h and then daily after application. Body weight at days 1 (pre-administration), 8 and 15.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
- Preliminary study:
- No mortality was observed in the preliminary study at 1000 and 2000 mg/kg in males and females.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Clinical signs:
- other: There were no changes in behaviour or clinical signs in any of the treated animals during the observation period. The local tolerance of the test article was good : no cutaneous lesion (erythema or oedema) was noted to the application site of the test art
- Gross pathology:
- There were no macroscopic 'findings that could be associated with treatment.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- From the results obtained under the experimental conditions employed, the LD0 by the cutaneous route in the rat, of the test article prepared as a paste at 76,46 % (W/V) and administered once only, as supplied, is greater than of equal to 2000 mg/kg for males and females combined, and for males and females separately. There were no effect of treatment in any of the parameters examined.
- Executive summary:
The test article was prepared as a paste at 76.46 % (W/V) in purified water and applied at the dose level of 2000 mg/kg, by the cutaneous route, in the Sprague-Dawley rat (5 males + 5 females). Mortality and abnormal clinical signs were noted 15 minutes after application, then at 1, 2 and 4 hours, and then daily for the l4 day study period. All the animals were weighed immediately before application of the test article (Day 1), on Days 8 and 15. A necropsy was performed for all the animals after the l4 day study period and the final observation (Day 15). No mortality nor any pathological clinical sign was noted. In conclusion, from the results obtained under the experimental conditions employed, the LD 0 (theoretical dose level which should not kill any animal during a study performed under identical conditions on a large population) for males and females combined and for males and females separately, may be expressed as follows: LD 0, by the cutaneous route, in the rat > 2000 mg/kg.
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