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EC number: 272-574-2 | CAS number: 68890-66-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
BIODEGRADATION IN WATER: SCREENING TESTS
AEROBIC TESTS - Table 1
Guideline | Test substance | Duration | Endpoint | Biodegradation | Result |
OECD 301B | Octopriox | 28d | CO2 Evolution | 6 % | not readily biodegradable under the test conditions |
OECD 301B | 2 -Pyridinol-N-oxid | 28d | CO2 Evolution | 77% | readily biodegradable |
OECD 301B | Octopirox Fe(III) | 28d | CO2 Evolution | 6 % | not readily biodegradable under the test conditions |
OECD 301D | Octopirox | 28d | O2 Consumption | 14% | not readily biodegradable under the test conditions |
OECD 302B | Octopirox | 28d | DOC removal | n.a. | sorption and biodegradation cannot be distinguished |
ANAEROBIC TEST - Table 2
Guideline | Test substance | Duration | Endpoint | Biodegradation | Result |
OECD 311 | Octopirox | 58d | Biogas Evolution | 0 -10 % | not biodegradable under the anaerobic test conditions |
BIODEGRADATION IN WATER: SIMULATION TEST IN SEWAGE TREATMENT PLANT
In the followingTable 3a Mass balance is given for the Simulation test system based on daily sampling over 24d
Effluent | Sludge | Total | Sorption to Glass& Tubing (estimated) | Remark | |
95% CI | 3.5 - 4.1 % | 85 - 95 % | 87 - 99 % | n.a. | analytical recovery forOctopirox was excellent |
arithm. mean | 3.8 % | 90 % | 93 % | < 5% | Biodegradation is minor |
For the Sewage treatment modelling the mass balance was set to 4% release to effluent and 96% to sewage sludge.
BIODEGRADATION IN SEDIMENT
No data are available. Based on the aquatic Biodegradation data listed above rapid biotic degradation is not expected. As Octopirox is rapidly degraded by Direct photolysis in water this is the rate determining step for the fate and not biodegradation. Therefore a Sediment Simulation Test is not warranted.
BIODEGRATION IN SOIL
No data are available. Based on the aquatic Biodegradation data listed above rapid biotic degradation is not expected. As Octopirox is rapidly degraded by Direct photolysis in water this is the rate determining step for the fate in the aquatic compartment and not biodegradation. As Direct Photolysis on soil surfaces may also occur a Soil Simulation test is not warranted.
SUMMARY ON BIODEGRADATION
AQUATIC BIODEGRADATION
Whereas 2 -Pyridinol-N-oxid which is the unsubstitueted moeity of Octopirox is readily biodegradable Octopirox is not. The reason is most likely the branched alkyl side chain. This means the rate for ultimate biodegradation of Octopirox compared to 2 -Pyridinol-N-oxide is much lower due to the slow degradation of the alkyl side chain. But Octopirox is not recalcitrant especially due to the rapid Direct photolysis in water (see IUCLID Section 5.1.3).
SEDIMENT & SOIL BIODEGRADATION
Based on the data from the biodegradation tests in water rapid biodegradation is not expected in sediment and soil. As Direct photolysis in water is rapid this is the rate determining step in the fate of Octopirox in water a Sediment Simulation test is not warranted. Direct photolysis can also occur on soil surfaces and therefore a Soil Simulation test is not warranted.
Additional information
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