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EC number: 237-415-3 | CAS number: 13776-88-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion, other
- Remarks:
- Study for skin irritation in vivo has been performed prior to the 2016 update of the REACH Regulation.
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 Jul - 05 Aug 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Aluminium metaphosphate
- EC Number:
- 237-415-3
- EC Name:
- Aluminium metaphosphate
- Cas Number:
- 13776-88-0
- Molecular formula:
- Al.3HO3P
- IUPAC Name:
- aluminium metaphosphate
- Details on test material:
- - Name of test material (as cited in study report): Aluminium metaphosphate
- Physical state: white solid powder
- Analytical purity: >95%
- Lot/batch No.: B57053A
- Expiration date of the lot/batch: 11.10.2013
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Zika
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Kaninchenbetrieb Kock, Warnkenhagen, Germany
- Age at study initiation: reported as young adults
- Weight at study initiation: 3.13-4.85 kg
- Housing: single-caged
- Diet: conventional laboratory diet (a half-and-half blend of “Holzenstolz Kaninchenverbrauchsfutter 2, Type 038” [Wilhelm Stroeh jr. GmbH & Co. KG, Germany] and “Rabbit maintenance, MuesliMash” [ssniff Spezialdiäten GmbH, Germany]), ad libitum
- Water: tap water (drinking quality), ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 3
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- moistened with 500 µL water
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g - Duration of treatment / exposure:
- 4 h
- Observation period:
- 4 days
Reading time points: 1, 24, 48 and 72 h after patch removal - Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: ca. 6 cm²
- Type of wrap if used: semiocclusive dressing
REMOVAL OF TEST SUBSTANCE
- Washing (if done): at the end of the exposure period with water
- Time after start of exposure: 4 h
SCORING SYSTEM: Draize scoring system
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- of all 3 animals
- Time point:
- other: mean from gradings at 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: reversibility not applicable
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- of all 3 animals
- Time point:
- other: mean from gradings at 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: reversibility not applicable
- Irritant / corrosive response data:
- Immediately after patch removal (one animal only): no skin reactions were observed.
1-72 h: no skin reactions were observed in any animal at any obervation time point. - Other effects:
- No further local or systemic effects were observed.
There were no effects in body weight development.
Any other information on results incl. tables
Table 1. Summary of skin reactions
Skin reaction |
Grading time point (after patch removal) |
Individual scores – Rabbit number and sex |
||
2013-17 female |
2013-18 female |
2013-26 female |
||
Erythema |
Immediately |
0 |
- |
- |
1 h |
0 |
0 |
0 |
|
24 h |
0 |
0 |
0 |
|
48 h |
0 |
0 |
0 |
|
72 h |
0 |
0 |
0 |
|
Mean score from gradings at 24, 48 and 72 h |
0 |
0 |
0 |
|
Edema |
Immediately |
0 |
- |
- |
1 h |
0 |
0 |
0 |
|
24 h |
0 |
0 |
0 |
|
48 h |
0 |
0 |
0 |
|
72 h |
0 |
0 |
0 |
|
Mean score from gradings at 24, 48 and 72 h |
0 |
0 |
0 |
Table 2. Summary of body weight (gain)
Rabbit number and sex |
Individual body weight (kg) |
Body weight change (kg) |
|
Day 0 |
Day 4 |
||
2013-17 female |
3.54 |
3.59 |
+0.05 |
2013-18 female |
4.85 |
4.89 |
+0.04 |
2013-26 female |
3.13 |
3.21 |
+0.08 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of the study, the test material caused no skin irritating/corrosive reactions. The individual mean values for erythema/eschar and edema from gradings at 24, 48 and 72 h were 0 in all three animals. Therefore, the material does not fulfil the criteria for classification according to Regulation (EC) No 1272/2008 (CLP) and the Globally Harmonized System of Classification and Labelling of Chemicals (GHS), and is thus considered to be not skin irritating.
CLP: not classified
GHS: not classified
DSD: not classified
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