Registration Dossier
Registration Dossier
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EC number: 283-291-9 | CAS number: 84604-14-8 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Rosmarinus officinalis, Labiatae.
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2002
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only short abstract available
Data source
Reference
- Reference Type:
- publication
- Title:
- Gas Chromatography: An Investigative Tool in Multiple Allergies to Essential Oils.
- Author:
- Dharmagunawardena B, Takwale A, Sanders KJ, Cannan S, Rodger A and Ilchyshyn A
- Year:
- 2 002
- Bibliographic source:
- Contact Dermatitis. 47(5): 288-292
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- case report
- Principles of method if other than guideline:
- Method: Single Patch test performed in a patient
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Rosemary, ext.
- EC Number:
- 283-291-9
- EC Name:
- Rosemary, ext.
- Cas Number:
- 84604-14-8
- Molecular formula:
- Not applicable for UVCB substance
- IUPAC Name:
- Essential oil of Rosmarinus officinalis L. (Lamiaceae) obtained from leaves, flowers and twigs by steam distillation
- Test material form:
- liquid
1
Method
- Type of population:
- other: clinical case presented with suspected allergic contact dermatitis
- Controls:
- No
- Route of administration:
- dermal
Results and discussion
- Results of examinations:
- - Rosemary oil showed a positive reaction (oedematous/vesicular reaction) on Day 4.
- It was found to be composed of terpineol (> 1 %), and α-pinene, linalool, and caryophylene (>10 %).
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Conclusions:
- Rosemary oil showed a positive reaction (oedematous/vesicular reaction) on Day 4. It was found to be composed of terpineol (>1 %), and α-pinene, linalool, and caryophylene (>10 %).
- Executive summary:
In a skin sensitisation study, a female patient (51 year old professional aromatherapist presented with suspected allergic contact dermatitis) was applied with occlusive patches containing rosemary oil diluted in white petrolatum, for 48 h. The reactions were observed at 30 min. after removal of patches and on Day 4. The composition of the oil was analysed using GC-MS chromatography.
Rosemary oil showed a positive reaction (oedematous/vesicular reaction) on Day 4. It was found to be composed of terpineol (>1 %), and α-pinene, linalool, and caryophylene (>10 %).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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