Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 237-331-7 | CAS number: 13749-61-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation: The test substance is not a dermal irritant.
Eye irritation: The test substance produced conjunctival irritation which cleared by day 7.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experimental start date: 11/13/07. Experimental termination date: 11/27/07
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Study conducted to GLP and in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not effect the quality of the relevant results.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Animals were received from Millbrook Breeding Labs.
- Age at study initiation: Approximately 3 months.
- Weight at study initiation: The pretest bodyweight range was 2.5 - 3.0 kg.
- Housing: 1 animal per cage in suspended wire cages. Bedding was placed beneath the cages and changed at least three times per week.
- Diet (e.g. ad libitum): Fresh PMI Rabbit Chow was provided daily.
- Water (e.g. ad libitum): Water was available ad libitum.
- Acclimation period: At least five days.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): The animal room was temperature controlled.
- Photoperiod (hrs dark / hrs light): 12 hour light/dark cycle. - Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- other: The test article was moistened with 0.5 ml of distilled water to form a paste
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): The test article was individually weighed, 0.5 g/site and moistened with 0.5 ml of distilled water to form a pasty consistency. - Duration of treatment / exposure:
- Exposure periods of 3 minutes (for initial animal), 1 hour (for initial animal) and 4 hours (all animals)
- Observation period:
- Up to 7 days.
- Number of animals:
- 3 (1 initial animal (male) and 2 subsequent animals (females)).
- Details on study design:
- SITE PREPARATION:
The day prior to application of the test article, the dorsal area of the trunk of each animal was clipped free of hair. The prepared site was approximately 10 x 10 cm and remained intact.
DOSING
Initially, one rabbit was dosed on sites #1, 2 and 3 with 0.5 g/site of the test article. The test article was individually weighed, 0.5 g/site and moistened with 0.5 ml of distilled water to form a pasty consistency. The test article was applied under a 2.5 x 2.5 cm gauze patch. Gentle pressure was applied to aid in the distribution of the test article over the prepared site. Each patch was secured with non-irritating tape. Site 1 was covered with a piece of plastic and held in place manually for the three-minute exposure. This method allowed partial removal of the wrapping to expose site #1 at 3 minutes post dose without disturbing sites #2 and 3. Sites 2 and 3 were wrapped with another piece of plastic in a semi-occlusive manner and secured with non-irritating tape. This method of wrapping aids in retaining the test patch in position and retards evaporation of volatile substances.
The wrapping and test article patch covering site #1 was removed at 3 minutes postdose and the site was gently washed with distilled water. A window was cut in the wrapping over site #2 at 1 hour after dosing. The patch was removed and the site gently washed with distilled water. At 4 hours postdose, the torso wrappings and patch covering site #3 were removed and the site gently washed with distilled water.
Since no evidence of a corrosive or severely irritating effect was observed in the initial animal, two additional animals were added to the study. The animals (females) were dosed with 0.5 g of the test article at site #3. After an exposure period of four hours, the wrappings and patches were removed and the sites gently washed with distilled water.
TYPE AND FREQUENCY OF OBSERVATIONS:
The test sites of all animals were scored for dermal irritation at 60 minutes after removal of wrappings. Site #3 (four-hour exposure) was scored at 24, 48 and 72 hours. Reactions were scored again on day 7 following patch removal.
Erythema and edema were scored according to teh numerical Driaze technique. The skin was also evaluated for ulceration and necrosis or any evidence of tissue destruction.
Draize scoring scheme:
Erythema & Eschar
No erythema: 0
Very slight erythema (barely perceptible): 1
Well defined erythema: 2
Moderate to severe erythema: 3
Severe erythema (beet redness) to slight eschar formation (injuries in depth): 4
Edema
No edema: 0
Very slight edema (barely perceptible): 1
Slight edema (edges of area well-defined by definite raising): 2
Moderate edema (raised approximately 1.0 mm): 3
Severe edema (raised more than 1.0 mm, extending beyond the area of exposure): 4
Body weights of all animals were recorded pre-test, 72 hours and at termination.
The general health of the animals was monitered at each observation time. All animals were sacrificed using CO2 following study termination. - Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- (Animal H510 - initial animal)
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 hours
- Remarks on result:
- other: Results from 4-hour exposure
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- (Animal H599)
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: Results from 4-hour exposure
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- (Animal H527)
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: Results from 4-hour exposure
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- (Animal H510 - initial animal))
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: Results from 4-hour exposure
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- (Animal H599)
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: Results from 4-hour exposure
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- (Animal H527)
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: Results from 4-hour exposure
- Irritant / corrosive response data:
- Dermal Observations:
Initial animal:
Erythema was absent at 60 minutes following patch removal following the 3 minute exposure and very slight at 60 minutes following the 1 and 4 hour exposures. Erythema was absent at 24, 48 and 72 hours following the 4 hour exposure. Edema was absent at 60 minutes after patch removal following the 3 minute exposure and following the 1 and 4 hour exposures. Edema was also absent at 24, 48 and 72 hours. On day 7, erythema and edema were absent.
Two additional animals:
Erythema was absent at 60 minutes following the 4 hour exposure and absent to slight at 24, 48 and 72 hours following the 4 hour exposure. On day 7, erythema was absent. Edema was absent at all observation points. - Other effects:
- Systemic Observations:
There were no abnormal physical signs noted during the observation period.
All body weight changes were normal. - Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test substance is not a dermal irritant.
- Executive summary:
Objective:
To determine the irritant or corrosive effects, if any, of a test article when applied dermally. The study was designed to comply with the standards set forth in OECD Guidelines for Testing Chemicals, Number 404, adopted April 24, 2002.
Method Synopsis:
Since the test article was suspected to be a severe dermal irritant, one healthy male New Zealand White rabbit was dosed dermally with NIPMMA Technical Grade. The test article (0.5 g) was applied dermally to three intact sites for an exposure period of three minutes on site #1, one hour on site #2 and four hours on site #3. Dermal reactions were scored at 60 minutes after each patch removal on all three sites. Site #3 was scored again at 24, 48 and 72 hours. Reactions were scored again on day 7 following patch removal. The skin was also evaluated for ulceration and necrosis or any evidence of tissue destruction at these time periods. Since the reaction of the initial animal did not produce a corrosive or severely irritating effect, two additional animals (females) were added to the study. The two animals were dosed at site #3 for a four hour exposure. Dermal reactions were scored at 60 minutes, 24, 48 and 72 hours and day 7 after patch removal. Body weights of all animals were recorded pretest, at 72 hours and at termination.
Summary:
Initial animal:
Erythema was absent at 60 minutes following patch removal following the 3 minute exposure and very slight at 60 minutes following the 1 and 4 hour exposures. Erythema was absent at 24, 48 and 72 hours following the 4 hour exposure. Edema was absent at 60 minutes after patch removal following the 3 minute exposure and following the 1 and 4 hour exposures. Edema was also absent at 24, 48 and 72 hours. On day 7, erythema and edema were absent.
Two additional animals:
Erythema was absent at 60 minutes following the 4 hour exposure and absent to slight at 24, 48 and 72 hours following the 4 hour exposure. On day 7, erythema was absent. Edema was absent at all observation points.
Systemic Observations:
There were no abnormal physical signs noted during the observation period.
All body weight changes were normal.
Conclusion:
The test substance is not a dermal irritant.
Reference
See attached background material for Table 1: Dermal Observations, Body Weights and Systemic Observations.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experimental Start Date: 11/06/07. Experimental Termination Date: 11/20/07
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Study conducted to GLP and in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not effect the quality of the relevant results.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: New Zealand White rabbits were received from Millbrook Breeding Labs, MA.
- Age at study initiation: Approximately 3 months old.
- Weight at study initiation: The pretest body weight was 2.6 - 3.1 kg.
- Housing: The animals were housed 1 per cage in suspended cages. Bedding was placed beneath the cages and changed at least three times per week.
- Diet (e.g. ad libitum): Fresh PMO Rabbit Chow was provided daily.
- Water (e.g. ad libitum): Water was available ad libitum.
- Acclimation period: At least five days.
Three animals (1 male, 2 females), free from evidence of occular irritation or abnormalities, were assigned to the study.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): The animal room was temperature controlled.
- Photoperiod (hrs dark / hrs light): 12-hour light/dark cycle. - Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml (equivalent 68.3 mg). - Duration of treatment / exposure:
- Single exposure
- Observation period (in vivo):
- Up to 7 days.
- Number of animals or in vitro replicates:
- 3 (1 male, 2 females)
- Details on study design:
- DOSING:
One eye of each rabbit was dosed. The contralateral eye served as a control. The test article (0.1 ml (equivalent (68.3 mg)) was placed by syringe-type applicator into the conjunctival sac, which was formed by gently pulling the lower eyelid away from the eye. After instillation, the lids were held together for approximately one second to ensure adequate distribution of the test article.
TYPE AND FREQUENCY OF OBSERVATIONS:
Using a Mini-Maglite flashlight equipped with a high intensity bulb, the treated eye of each rabbit was examined for irritation of the cornea, iris and conjunctiva at 1, 24, 48 and 72 hours in all three animals and to day 7 in the two additional animals. Sodium fluorescein dye procedures were used at the 24 and 48 hour observation intervals for the initial animal and at the 24 hour observation interval for the two additional animals. The eye was examined with the aid of an ultraviolet light source.
Ocular reactions were graded according to the numerical Draize technique (see attached background matertial). Additional signs were described.
Body weights were recorded pretest and at termination.
The general health of the animals was monitered at each observation time. All animals were humanely sacrificed using CO2 following study termination. - Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- (Animal 1 - H504)
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: lack of normal luster observed at 24 hour observation
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- (Animal 2 - H512)
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- (Animal 3 - H526)
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- (Animal 1 - H504)
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- (Animal 2 - H512)
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- (Animal 3 - H526)
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- mean
- Remarks:
- (Animal 1 - H504)
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- mean
- Remarks:
- (Animal 2 - H512)
- Time point:
- 24/48/72 h
- Score:
- 0.67
- Max. score:
- 3
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- mean
- Remarks:
- (Animal 3 - H526)
- Time point:
- 24/48/72 h
- Score:
- 1.67
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- (Animal 1 - H504)
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- (Animal 2 - H512)
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- (Animal 3 - H526)
- Time point:
- 24/48/72 h
- Score:
- 0.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Irritant / corrosive response data:
- Ocular Findings (see Table 1 - attached back ground material).
There was no corneal opacity or iritis noted at any observation period. Conjunctival irritation was noted in 3/3 eyes and cleared by day 7. - Other effects:
- Systemic Observations (see Table 1 - attached back ground material).
All animals appeared normal during the observation period. - Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test substance produced conjunctival irritation which cleared by day 7.
- Executive summary:
Objective:
To determine the irritant and/or corrosive effects, if any, of a test article when instilled into the rabbit eye. The study was designed to comply with the standards set forth in OECD Guidelines For Testing Chemicals, Number 405, adopted April 24, 2002.
Method Synopsis:
Initially, one healthy New Zealand White rabbit (female), free from evidence of ocular irritation and corneal abnormalities, was dosed with NIPMAA Technical Grade. The test article (0.1 ml (equivalent (68.3 mg)) was placed into the conjuctival sac of one eye. Based on the reactions of the initial animal, two additional animals (1 male, 1 female) were added to the study and dosed in the same manner. The eyes were examined and scored by the Draize technique at 1, 24, 48 and 72 hours in all three animals and to day 7 in the two additional animals. Sodium fluorescein dye procedures were used at the 24 and 48 hour observation intervals for the initial animal and at the 24 hour observation interval for the two additional animals. The primary eye irritation score for each rabbit, each day, was calcuated. Body weights were recorded pretest and at termination.
Summary:
There was no corneal opacity or iritis noted at any observation period. Conjunctival irritation was noted in 3/3 eyes and cleared by day 7.
All animals appeared normal during the observation period.
Conclusion:
NIPMAA Technical Grade produced conjunctival irritation which cleared by day 7.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin Irritation/Corrosion:
Objective:
To determine the irritant or corrosive effects, if any, of a test article when applied dermally. The study was designed to comply with the standards set forth in OECD Guidelines for Testing Chemicals, Number 404, adopted April 24, 2002.
Method Synopsis:
Since the test article was suspected to be a severe dermal irritant, one healthy male New Zealand White rabbit was dosed dermally with the test item. The test article (0.5 g) was applied dermally to three intact sites for an exposure period of three minutes on site #1, one hour on site #2 and four hours on site #3. Dermal reactions were scored at 60 minutes after each patch removal on all three sites. Site #3 was scored again at 24, 48 and 72 hours. Reactions were scored again on day 7 following patch removal. The skin was also evaluated for ulceration and necrosis or any evidence of tissue destruction at these time periods. Since the reaction of the initial animal did not produce a corrosive or severely irritating effect, two additional animals (females) were added to the study. The two animals were dosed at site #3 for a four hour exposure. Dermal reactions were scored at 60 minutes, 24, 48 and 72 hours and day 7 after patch removal. Body weights of all animals were recorded pretest, at 72 hours and at termination.
Summary:
Initial animal:
Erythema was absent at 60 minutes following patch removal following the 3 minute exposure and very slight at 60 minutes following the 1 and 4 hour exposures. Erythema was absent at 24, 48 and 72 hours following the 4 hour exposure. Edema was absent at 60 minutes after patch removal following the 3 minute exposure and following the 1 and 4 hour exposures. Edema was also absent at 24, 48 and 72 hours. On day 7, erythema and edema were absent.
Two additional animals:
Erythema was absent at 60 minutes following the 4 hour exposure and absent to slight at 24, 48 and 72 hours following the 4 hour exposure. On day 7, erythema was absent. Edema was absent at all observation points.
Systemic Observations:
There were no abnormal physical signs noted during the observation period.
All body weight changes were normal.
Conclusion:
The test substance is not a dermal irritant.
Eye Irritation/Corrosion:
Objective:
To determine the irritant and/or corrosive effects, if any, of a test article when instilled into the rabbit eye. The study was designed to comply with the standards set forth in OECD Guidelines For Testing Chemicals, Number 405, adopted April 24, 2002.
Method Synopsis:
Initially, one healthy New Zealand White rabbit (female), free from evidence of ocular irritation and corneal abnormalities, was dosed with NIPMAA Technical Grade. The test article (0.1 ml (equivalent (68.3 mg)) was placed into the conjuctival sac of one eye. Based on the reactions of the initial animal, two additional animals (1 male, 1 female) were added to the study and dosed in the same manner. The eyes were examined and scored by the Draize technique at 1, 24, 48 and 72 hours in all three animals and to day 7 in the two additional animals. Sodium fluorescein dye procedures were used at the 24 and 48 hour observation intervals for the initial animal and at the 24 hour observation interval for the two additional animals. The primary eye irritation score for each rabbit, each day, was calcuated. Body weights were recorded pretest and at termination.
Summary:
There was no corneal opacity or iritis noted at any observation period. Conjunctival irritation was noted in 3/3 eyes and cleared by day 7.
All animals appeared normal during the observation period.
Conclusion:
The test substance produced conjunctival irritation which cleared by day 7.
Justification for selection of skin irritation / corrosion endpoint:
The study has been conducted according to OECD Guideline 404 and GLP and is adequately reported. The study has been assigned a reliability 1.
Justification for selection of eye irritation endpoint:
The study has been conducted according to OECD Guideline 405 and GLP and is adequately reported. The study has been assigned a reliability 1.
Justification for classification or non-classification
The results from skin irritation and eye irritation studies were evaluated according to the Classification, Labelling and Packaging Regulation (CLP).
Skin irritation:
The test item produced a maximum individual mean score of 1 for erythema (based on scores at 24, 48 and 72) in one animal only and therefore does not meet the criteria for classification according to the Classification, Labelling and Packaging Regulation (CLP).
Eye irritation:
The test item does not meet the criteria for classification according to the Classification, Labelling and Packaging Regulation (CLP), as although some minor conjunctival irritation was observed, all effects cleared by day 7 for 1 animal and by 72 hours for 2 animals. The effects were insufficient to meet the criteria for classification according to the Classification, Labelling and Packaging Regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.