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EC number: 689-137-0 | CAS number: 247569-56-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 2012 - August 2012
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- yes
- Remarks:
- Due to a misinterpretation about 50 mg/l test item and about 30 mg/l reference substance were tested in the toxicity control as a mixture and not about 50 mg/l test item and about 60 mg/l reference substance as described in the study plan. No influence.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-fluoro-5-methanesulfonylbenzoic acid
- EC Number:
- 689-137-0
- Cas Number:
- 247569-56-8
- Molecular formula:
- C8 H7 F O4 S
- IUPAC Name:
- 2-fluoro-5-methanesulfonylbenzoic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- BMG sample no. M1204-02810-01
Physical form Solid
Batch no BS11020465
Purity 99.5%, treated as 100% pure
CAS no. 247569-56-8
Theoretical oxygen demand 1.320 mg O2/mg (calculated according to chapter 5.2)
Test substance storage At room temperature
Stability Stable under storage conditions
Expiry date 21 May 2013
Test substance 75.8 mg/l (100 mg ThOD/l)
Reference substance 60.0 mg/l (97.4 mg ThOD/l)
Toxicity control 75.0 mg/l of the test substance and 30.0 mg/l of reference substance (149 mg ThOD/l)
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Duration of test (contact time):
- ca. 28
Results and discussion
% Degradation
- Parameter:
- % degradation (O2 consumption)
- Sampling time:
- 28 d
- Remarks on result:
- other: No significant biodegradability of test substance based on O2 consumption was observed during 28 days as compared to the theoretical oxygen demand.
- Details on results:
- Determination of biodegradation
Based on the data of the individual O2 determinations (Table 2, Figure 1), no significant
biodegradability in the Manometric Respirometry Test of 5-Methylsulfonyl-
2-fluorobenzoic acid RO4638493 was observed after 28 days (Figure 1).
The positive control, sodium benzoate, reached 90% biodegradation after 14 days, thus confirming
suitability of inoculum and test conditions (Table 3, Figure 2).
The respective DOC concentrations at the beginning and at the end of the test after
28 days were (in mg/l):
33.4 (1) and 41.5 for the test units (mean of two replicates)
<0.5 and 5.34 for the inoculum blank (mean of two replicates)
68.5 (1) and 7.51 for the procedure control (mean of two replicates)
(1) theoretical concentration based on molecular formula
The calculated biodegradation based on the DOC measurements confirmed the results based on the ThOD with no significant biodegradability for 5-Methylsulfonyl-2-fluorobenzoic acid RO4638493 and 97% for sodium benzoate, respectively.
5-Methylsulfonyl-2-fluorobenzoic acid RO4638493 is not biodegradable in the Manometric Respirometry Test.
Additional controls
At the applied initial test concentration of 75.0 mg/l the test substance showed no significant toxic effect on the microbial population, since the biodegradation of the mixture (test substance + reference compound sodium benzoate) was within the expected theoretical value during the whole test period (Table 3, Figure 2). The test was considered valid, since more than 25% degradation occurred within 14 days.
5-Methylsulfonyl-2-fluorobenzoic acid RO4638493 was not abiotically degraded (by processes using O2) during the whole test period of 28 days in the asence of microorganisms as confirmed by the lack of oxygen consumption (Table 3).
Further remarks
At the end of the test the pH value of both inoculum blanks and the procedure control was 7.3 and 7.5, respectively. The pH values of the test units and both controls were 7.3, 7.5 and 7.2, respectively.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- 5-Methylsulfonyl-2-fluorobenzoic acid RO4638493 is not biodegradable in the Manometric Respirometry Test.
- Executive summary:
The biodegradability of 5-Methylsulfonyl-2-fluorobenzoic acid RO4638493 exposed to microorganisms derived from activated sludge of a municipal sewage treatment plant was investigated under aerobic static exposure conditions.
No significant biodegradability of 5-Methylsulfonyl-2-fluorobenzoic acid RO4638493 based on O2 consumption was observed during 28 days as compared to the theoretical oxygen demand (ThOD).
The procedure control sodium benzoate reached 90% biodegradation after 14 days, thus confirming suitability of inoculum and test conditions.
The calculated biodegradation based on the DOC measurements confirmed the results based on the ThOD with no significant biodegradability for 5-Methylsulfonyl- 2-fluorobenzoic acid RO4638493 and 97% for sodium benzoate, respectively.
5-Methylsulfonyl-2-fluorobenzoic acid RO4638493 is not biodegradable in the Manometric Respirometry Test.
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