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EC number: 608-748-5 | CAS number: 324763-46-4
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 5.1. - 3.2. 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-E (Determination of the "Ready" Biodegradability - Closed Bottle Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- (3S,5S)-5-[(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl]-3-(propan-2-yl)oxolan-2-one
- EC Number:
- 608-748-5
- Cas Number:
- 324763-46-4
- Molecular formula:
- C25 H39 N3 O5
- IUPAC Name:
- (3S,5S)-5-[(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl]-3-(propan-2-yl)oxolan-2-one
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- sewage, predominantly domestic (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge: sewage from the output of the second stage of a sewage treatment plant
- Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 3.64 - 3.65 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Test temperature: 20 +/- 1 °C
- Continuous darkness: yes
TEST SYSTEM
- Number of culture flasks/concentration: 2x 9
SAMPLING
- Sampling frequency: Day 0, 3, 7, 10, 14, 17, 21, 24, 28
CONTROL AND BLANK SYSTEM
- Inoculum blank: 2x 9 replicates
- Reference substance: 2x 9 replicates
- Toxicity control: 2x 5 replicates
- 9 replicates for determination of oxidized nitrogen forms
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
% Degradation
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0
- Sampling time:
- 28 d
BOD5 / COD results
- Results with reference substance:
- Degradation kinetic:
Day 0: 0%
Day 3: 60.3%
Day 7: 78.8%
Day 28: 85%
Applicant's summary and conclusion
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- In this 28 day study of ready biological degradability the decomposition of 0 % of the test substance was attained.
The test substance is not readily biodegradable.
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