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Diss Factsheets
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EC number: 205-201-9 | CAS number: 135-57-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- other: Assessment, including consideration of transformation products
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- There is no evidence that the substance is biologically active with no toxic effects reported to mammals or other organisms.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Version / remarks:
- Review of data
- Principles of method if other than guideline:
- Because it is known that the substance quickly hydrolyses with a DT50 ca 1 day, an evaluation has been made to assess the potential toxicity of the identified transformation products
Test material
- Reference substance name:
- N,N’-dithiodi-o- phenylenedibenzamide
- IUPAC Name:
- N,N’-dithiodi-o- phenylenedibenzamide
- Reference substance name:
- N,N'-dithiodi-o-phenylenedibenzamide
- EC Number:
- 205-201-9
- EC Name:
- N,N'-dithiodi-o-phenylenedibenzamide
- Cas Number:
- 135-57-9
- Molecular formula:
- C26H20N2O2S2
- IUPAC Name:
- N-{2-[(2-benzamidophenyl)disulfanyl]phenyl}benzamide
- Details on test material:
- - Name of test material (as cited in study report): Pepton 22
- Physical state: Yellow powder
- Analytical purity: 95.97%
- Lot/batch No.: 15/2673/07
- Storage condition of test material: 4 deg C over silica gel
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- This is the main starting material.
Two key transformation products assessed include:
N-((1E)-4-oxo-2-sulfanylcyclohexa-2,5-dien-1-ylidene) benzamide
N-(2-((2-aminophenyl)disulfanyl)phenyl) benzamide
Test animals
- Species:
- other: Assessment ased mainly on rat data
Administration / exposure
- Route of administration:
- oral: unspecified
- Details on exposure:
- The review is based on potential toxicity of the transformation products that woudl form on ingestion or from secondary exposure in food or water.
Therefore, only oral exposure has been considered.
Doses / concentrations
- Dose / conc.:
- 1 000 mg/kg bw/day (nominal)
- Remarks:
- Of reviews for similar substances, this was the highest dose
Some substances were dosed lowed according to parental toxicity
Examinations
- Maternal examinations:
- Of studies reviews, care was taken to ensure that maternal toxicity was recorded
Results and discussion
Results: maternal animals
Effect levels (maternal animals)
- Dose descriptor:
- other: Assessment
- Remarks on result:
- other: Maternal toxicity seen in some substances
- Remarks:
- See results of review
Maternal abnormalities
- Abnormalities:
- no effects observed
- Description (incidence and severity):
- No reproductive abnormalities reported in data reviewed
Results (fetuses)
Effect levels (fetuses)
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Remarks:
- No reproductive abnormalities reported in data reviewed
Fetal abnormalities
- Abnormalities:
- no effects observed
- Description (incidence and severity):
- No reproductive abnormalities reported in data reviewed
Effects on survival, size and general health seen for some substances where there was significant maternal toxicity.
Overall developmental toxicity
- Developmental effects observed:
- no
Applicant's summary and conclusion
- Conclusions:
- Because it is known that the substance quickly hydrolyses with a DT50 ca 1 day, an evaluation has been made to assess the potential toxicity of the identified transformation products
From a review of derivatives of benzamines, benzamides and toluamides, there is no evidence that this class of substance is toxic for reproduction or has potential for developmental toxicity.
This review included a well-evaluated herbicide and a biocide that had been extensively evaluated.
Some of the substances showed parental toxicity (specifically toluamides) but despite this, there were no adverse developmental effects at concentrations not causing toxicity to parental animals.
In view of the apparent low toxicity of the class if substance, including the absence of effects in testing already performed for registration of this substance, and also taking into effect limited exposure from industrial uses only and taking into account the rapid environmental transformation of the substance, there is considered to be no value in performing further animal testing.
As the substance is a potential sensitiser, it is recommended that workers at the limited number of manufacturing sites and sites where it is consumed during use take precautions when handling to minimise exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.