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EC number: 209-952-3 | CAS number: 598-78-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2 generation
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with no deviations
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 416: Two Generation Reproduction
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- in vivo
Test material
- Reference substance name:
- 2-chloropropionic acid
- EC Number:
- 209-952-3
- EC Name:
- 2-chloropropionic acid
- Cas Number:
- 598-78-7
- Molecular formula:
- C3H5ClO2
- IUPAC Name:
- 2-chloropropanoic acid
- Details on test material:
- Test materials: L-CPA
Description: Colourless Liquid
Lot/Batch: Bx 19 (Assigned CTL ref YO6206/004)
Purity: 96.6% w/w by calculation of which 92.7% L- and 4% D-
Stability: chemical stability of L-CPA in diet at concentrations 150 and 1500 ppm was considered satisfactory for 7 days at room temperature or 92 days in frozen storage.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Alpk:APfSD
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Test animals
Species: Rat
Strain: Alpk:APfSD (Wistar-derived)
Age: 22 days old
Weight at dosing: 84.1 – 93.5g for F0 adults (includes males and females)
Source: Zeneca Pharmaceuticals, Alderley Park, Macclesfield, Cheshire. UK
Acclimatisation period: 7 days prior to start of dosing
Diet: CT1, ad libitum
Water: Filtered mains water, ad libitum
Housing: Animals were housed, sexes separately, in multiple rat racks.
Environmental conditions
Temperature: 21 +/- 2°C
Humidity: 55 +/- 15%
Air changes: At least 15 per hour
Photoperiod: 12 hours of light/12 hours of darkness
Administration / exposure
- Route of administration:
- oral: feed
- No. of animals per sex per dose:
- Groups of 26 male and 26 female rats (F0 adults) weaning Alpk:APfSD rats were fed diets containing 0 (control), 150, 500 or 1500ppm L-chloropropionic acid (L-CPA) the racemic version of A-CPA.
- Details on study design:
- Groups of 26 male and 26 female rats (F0 adults) weaning Alpk:APfSD rats were fed diets containing 0 (control), 150, 500 or 1500ppm L-chloropropionic acid (L-CPA) the racemic version of A-CPA. The breeding programme was repeated in the controls, 150 and 500ppm groups with the F1 adults selected from the F1A offspring to produce the F2A litters after a 10 week pre-mating period. The 150 and 500ppm test diets were fed continuously to the males and females through the study. The 1500ppm test diet was fed continuously to the females during the first generation lactation phase when control diet was fed. At this stage the F1A litters in the 1500ppm group were between days 11 and 17 post partum. The 1500ppm diet was fed continuously to males up to termination.
- Statistics:
- Group mean values of the treated groups were compared with the appropriate control group using Student t-test (two sided) with the exception of pup organ weights.
Results and discussion
Effect levels
- Dose descriptor:
- NOEL
- Remarks:
- 500ppm L-CPA
- Remarks on result:
- not measured/tested
- Remarks:
- Effect level not specified
Observed effects
During lactation in the first generation bizarre behaviour or clonic convulsions were recorded for several females in the 1500ppm group on one or two days between days 5 and 15 post partum.
Offspring findings related to L-CPA were confined to the F1a litters of the 1500 ppm group. These findings were associated with the poor survival seen especially after day 15 in these litters. These were considered by the study director to reflect increased maternal toxicity rather than a direct response to the pups. This in turn almost certainly reflects the substantially increased feed intake during lactation, which at a constant dietary inclusion level gives a substantial increase of the received dose to the dams.
Applicant's summary and conclusion
- Conclusions:
- Based on this study there are no reproductive effects of L-CPA but the neurotoxic potential of the compound is confirmed in the parental animals.
- Executive summary:
Clear signs of toxicity were seen in male and female rats diets containing 1500ppm L-CPA in the form of neurotoxicity with associated brain lesions and reductions in bodyweight gain and food consumption. There were no effects on fertility or offspring parameters at birth and the high incidence of F1a pup mortality in the 1500 ppm group was attributed to increased maternal toxicity most probably as a result of the increased food consumption, and therefore dose rate, during lactation. The no observed effect level was 500 ppm L-CPA in diet.
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