Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 268-596-7 | CAS number: 68130-53-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to microorganisms
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data based on the inhibition control of a ready biodegradability study. This approach is in accordance with the Guidance on information requirements and chemical safety assessment (Chapter R.7b: Endpoint specific guidance, ECHA 2012).
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- GLP compliance:
- no
- Test organisms (species):
- activated sludge, domestic
- Details on inoculum:
- - Source of inoculum/activated sludge: Activated sludge from the aeration basin of the domestic sewage treatment plant in Lachen-Speyerdorf, Germany (2008-05-08)
- Preparation of inoculum for exposure: The sludge was aerated continually, washed with and re-suspended in mineral medium.
- Initial biomass concentration: 25 mg suspended solids/L - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 14 d
- Test temperature:
- 22 ± 1°C
- Nominal and measured concentrations:
- Nominal test substance concentration:
30 ± 2 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: 2000 mL-SCHOTT-flasks
- Fill volume: 1500 mL
- Aeration: with purified, CO2-scribbed, moistened air
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Mineral medium according to OECD guideline
EFFECT PARAMETERS MEASURED:
CO2 evolution on day 0, 2, 4, 7, 9, 11 and 14 - Reference substance (positive control):
- yes
- Remarks:
- Anilin
- Key result
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 30.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Result of toxicity control from ready biodegradability test
- Results with reference substance (positive control):
- The reference material (Anilin) was degraded by 3.5% after 7 days, 60% pass level was reached.
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Study period:
- 14 May 1998
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP Guideline study with acceptable restrictions: No analytical purity is given. , no analytical monitoring)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: Test substanz was emulsified using Ultra-Turrax. - Test organisms (species):
- activated sludge, domestic
- Details on inoculum:
- - Laboratory culture: Activated sludge from sewage plant Bempflingen, Germany
- Preparation of inoculum for exposure: Activated sludge was washed with tap water twice, afterwards centrifuged and the dry residue was determined. The amount of the sludge was weighed per liter, which was corresponded to 4 g dry mass. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 3 h
- Hardness:
- not stated
- Test temperature:
- 20 ± 2 °C
- pH:
- not stated
- Dissolved oxygen:
- > 6.5 mg/L
- Nominal and measured concentrations:
- Nominal: 10000 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: beaker
- Material: glass; Size: 1 L; Fill volume: 500 mL
- Aeration: continously to reach an oxygen content > 6.5 mg/L
- No. of vessels per concentration: 1
- No. of vessels per control: 2
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: dechlorinated tap water
EFFECT PARAMETERS MEASURED: Respiration inhibition by decrease of oxygen content was measured in 15-minutes-pulses over a test period of 3 h using an OXI-meter. - Reference substance (positive control):
- yes
- Remarks:
- 3,5 dichlorphenol
- Key result
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 10 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Key result
- Duration:
- 3 h
- Dose descriptor:
- EC10
- Effect conc.:
- > 10 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Results with reference substance (positive control):
- - Results with reference substance valid? Yes, result is in the range of 5 to 30 mg/L
- Relevant effect levels: EC50 = 5 mg/L
Referenceopen allclose all
Degradation (%) the toxicity control in ready biodegradability study following OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
Day |
Toxicity control |
2 |
1.3 |
4 |
41.8 |
7 |
65.9 |
9 |
70.4 |
11 |
74.4 |
14 |
80.4 |
17 |
77.2 |
23 |
84.3 |
29 |
87.9 |
An increase about 43% of respiration rate could be observed at the nominal tested concentration of 10000 mg/L in comparison to the control.
Table 1: Respiration rate of control, reference and test substance and inhibition of the respiration rate of test and reference substance (*A negative sign means an increase of the respiration)
|
Replicates |
Concentration [mg/L] |
Respiration rate [mg O2/L x h] |
Inhibition [%] |
Control |
1 |
|
24.0 |
- |
Referenz |
1 |
2.5 10 30 |
22.0 11.0 5.0 |
10.2 55.1 79.6 |
Test substance |
1 |
10000 |
35.0 |
-43.0* |
*: negative value indicate an increase of respiration
Description of key information
No relevant studies are available for decanoic acid, mixed esters with heptanoic acid, octanoic acid and trimethylolpropane. Two studies that evaluated the toxicity to aquatic microorganisms are available for closely related structural analogues (CAS 11138-60-6 and CAS 78-16-0).
Key value for chemical safety assessment
- EC50 for microorganisms:
- 10 000 mg/L
Additional information
Two studies that evaluated the toxicity to aquatic microorganisms are available for closely related structural analogues:
The first study was conducted with CAS 11138-60-6 using activated sludge (domestic) according to OECD 209. It showed an increase about 43% of respiration rate at the nominal tested concentration of 10000 mg/L in comparison to the control. No inhibition of respiration rate was observed. Therefore the EC50 and EC10 (3h) can be stated as > 10000 mg/L (nominal).
The second study with CAS 78-16-0 was based on the inhibition control of a ready biodegradability study. Since more than 80.4% degradation occurred in the toxicity control, the substance is with a high probablity not toxic to aquatic microorganisms. The test item concentration in the toxicity control of 30.4 mg/L can be used as NOEC value for the toxicity to aquatic microorganisms.
Therefore, by read-across, decanoic acid, mixed esters with heptanoic acid, octanoic acid and trimethylolpropane is not considered to be toxic to aquatic microorganisms.
A report justifying the read-across approach is included in IUCLID Chapter 13.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.