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Diss Factsheets
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EC number: 459-330-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12/10/1992 - 19/03/1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 1,1,2,2-tetrafluoroethyl-2,2,2-trifluoroethyl ether
- EC Number:
- 609-858-6
- Cas Number:
- 406-78-0
- Molecular formula:
- C4H3F7O
- IUPAC Name:
- 1,1,2,2-tetrafluoroethyl-2,2,2-trifluoroethyl ether
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Animals were 5 weeks old at the time of dosing. Male body weights varied between 104.5 - 120.7g for males and 100.1 - 107.5 for females. No deviations to the environment in which the animals were housed were noted during the course of the study.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- Animals were fasted overnight prior to the dosing.
- Doses:
- Preliminary dose range-finder was performed using 20, 100, 500 and 2,000 mg/kg for 7 days to determine experimental dose. As no mortality was observed in any study, the top dose was selected for the final study.
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- Both clinical and mortality observations were conducted hourly for 6 hours post-dosing, and twice daily on subsequent days.
- Statistics:
- Mean values and standard deviations of the body weights were calculated for both sex groups.
Results and discussion
- Preliminary study:
- No mortality observed.
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality observed in any group.
- Clinical signs:
- other: Mucous in the stool of animals from the control group was noted between 30 mins to 1 hour after dosing. This ws recorded in both males and females.
- Gross pathology:
- No abnormalities were noted.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No mortality or adverse clinical signs were noted in the test group or the control group. Therefore, the medial lethal dose (LD50) for 1,1,2,2-tetrafluoroethyl-2,2,2-trifluoroethyl ether is >2000 mg/kg bw/day.
- Executive summary:
An OECD 401 Acute Oral Toxicity study was performed using the test substance 1,1,2,2-tetrafluoroethyl-2,2,2-trifluoroethyl ether using rats. A high dose, 2000 mg/kg bw/day, was selected for the final study, and the control group received a concurrent vehicle control (olive oil). No mortality or adverse effects were noted in the test group or the control group. Some minor effects were noted in the control group, however these were not observed in the test group, and are likely due to the vehicle.
Due to the absence of mortality, the LD50 for the test substance is considered to be >2000 mg/kg bw/day. 1,1,2,2-tetrafluoroethyl-2,2,2-trifluoroethyl ether is not considered to be acutely toxic via the oral route.
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