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EC number: 700-641-2 | CAS number: 1261240-30-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- 4-tert-butyl-2-(5-tert-butyl-2-oxo-2,3-dihydro-1-benzofuran-3-yl)phenyl 3,5-di-tert-butyl-4-hydroxybenzoate
- EC Number:
- 700-641-2
- Cas Number:
- 1261240-30-5
- Molecular formula:
- C37H46O5
- IUPAC Name:
- 4-tert-butyl-2-(5-tert-butyl-2-oxo-2,3-dihydro-1-benzofuran-3-yl)phenyl 3,5-di-tert-butyl-4-hydroxybenzoate
- Test material form:
- other: Crystalline powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Age and body weight range of test animals: nine weeks old and 227 to 235 grams.
Number and sex: a total of 6 females were used in this study. Animals were quarantined and acclimated for 6 days prior to study. Ear-notch and cage tags were used for animal identification. Each cage was identified by a card indicating cage number, study number , dose level, sex and animal IDs.
Environmental conditions: The animals were housed individually in a Polycarbonate (PC) cage (three rats per cage). The animals were housed in room C438 for three days, then transferred to room C411 due to the air pressure problem. The daily mean temperature was 20.6 - 21.3 degree C in C438 and 20.5 - 21.5 degree C in C411. The daily mean relative humidity was 50.8 - 57.3% in C438 and 29.2 - 58.6% in C411. THe 12-hr/12-hr light/dark cycle with light on at 6:00 AM and off at 6:00 PM was maintained.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Methyl Cellulose at 0.5% (w/v) was used for dosing formulation preparation.
- Doses:
- The starting dose of 2000 mg/kg was used.
- No. of animals per sex per dose:
- 6
- Details on study design:
- Three female animals were used for the starting dose of 2000 mg/kg. Because neither mortality nor body weight loss over 20% was observed within 3 days, three more females were administered at the same dose. Total 6 animals were administered test article formulation at dose of 2000 mg/kg with concentration of 100 mg/mL. The dosing volume was 20 mL/kg.
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No animal death was observed.
- Clinical signs:
- other: No clinical signs were observed.
- Gross pathology:
- No gross lesion was observed.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- After the animals were administered to the dose level of 2000 mg/kg, neither animal death nor clinical sign was found during the entire study period. The body weights were increased during the study period. At animal necropsy, no gross lesion was found in all rats. Based on the data obtained from this study, the test substance would be assigned to GHS Category 5/unclassified and the harmonized LD50 cut-off values is 5000 mg/kg.
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