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Diss Factsheets
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EC number: 224-594-8 | CAS number: 4422-95-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15-03-2022 to 28-04-2022
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Guideline study performed under GLP. All relevant validity criteria were met.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7200 (Melting Point / Melting Range)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- inspected: February 2022 ; signed: April 2022
- Type of method:
- differential scanning calorimetry
- Key result
- Melting / freezing pt.:
- ca. 36.9 °C
- Atm. press.:
- ca. 999 hPa
- Decomposition:
- no
- Sublimation:
- no
- Remarks on result:
- other: mean melting point (n = 3)
- Conclusions:
- The melting temperature of the test item has been determined to be 36.9°C (or 310.05 K). At above this temperature the substance is considered to be liquid.
- Executive summary:
The melting temperature was determined using OECD TG 102 and EU Method A.1 with the Differential Scanning Calorimetry method under GLP. The guideline defines the melting temperature as: the temperature at which the phase transition from solid to liquid state occurs at atmospheric pressure and this temperature ideally corresponds to the freezing temperature. Eight experiments were conducted. Three experiments for melting point determination specifically. The experiments were performed under a flow of nitrogen at atmospheric pressure (999 ± 18 hPa) using a gold crucible sample container, that was closed with a lid in which a small hole was drilled/manually punched due to potential corrosivity of the test item. The melting temperature was determined as the mean melting temperature of Experiment 1 (36.929°C), Experiment 2 (37.122°C) and Experiment 7 (36.601°C). It was concluded that the melting temperature of the test item has been determined to be 36.9°C (or 310.5.5 K). At above this temperature the substance is considered to be liquid.
Reference
Main study
Eight experiments were conducted in total. Experiment 1, 2 and 7 were used for MP evaluation and stared at -25 Initial temperature: -25°C.
Experiment 2, 4 and 8 were used for BP determination.
Experiment 3, 5 and 7 were not used (e.g. poor peak shape/peak broadening of endotherms – see comments below).
Melting point
The melting temperature was determined as the mean melting temperature of Experiment 1 (36.929°C), Experiment 2 (37.122°C) and Experiment 7 (36.601°C).
Boiling point
Within Experiment 3, 5 and 7 the offsets obtained for the broader endothermic peaks were not taken into account as these are considered less reliable. It is considered the causes of the broader endotherm experiments could be an artefact of the use of gold sample containers and/or their manual perforation as a consequence of the potential corrosivity of the test item. The boiling effects with reliable endothermic peak shapes showed a spread over the obtained results, a range of the boiling temperature was determined based upon: Experiment 2 (325.740°C), Experiment 4 (319.531°C) and Experiment 8 (319.871°C). Within experiments there was no evidence of decomposition noted. In all experiments, pon completion of the experiment it was observed that the test item had evaporated from the (gold) sample container.
The melting temperature of the test item was 36.9°C.
The boiling temperature (range) of the test item was 319.5°C – 325.7°C
Description of key information
Mp: 36.9°C (or 310.05 K) at 1 atmosphere, OECD TG 102 : DSC Method, 2022
Key value for chemical safety assessment
- Melting / freezing point at 101 325 Pa:
- 36.9 °C
Additional information
Key Study : OECD TG 102, 2022 : The melting temperature was determined using OECD TG 102 and EU Method A.1 with the Differential Scanning Calorimetry method under GLP. The guideline defines the melting temperature as: the temperature at which the phase transition from solid to liquid state occurs at atmospheric pressure and this temperature ideally corresponds to the freezing temperature. Eight experiments were conducted. Three experiments for melting point determination specifically. The experiments were performed under a flow of nitrogen at atmospheric pressure (999 ± 18 hPa) using a gold crucible sample container, that was closed with a lid in which a small hole was drilled/manually punched due to potential corrosivity of the test item. The melting temperature was determined as the mean melting temperature of Experiment 1 (36.929°C), Experiment 2 (37.122°C) and Experiment 7 (36.601°C). It was concluded that the melting temperature of the test item has been determined to be 36.9°C (or 310.5.5 K). At above this temperature the substance is considered to be liquid.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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