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Diss Factsheets
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EC number: 203-950-6 | CAS number: 112-24-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study was not performed accoding to guideline or GLP. Information on substance composition/purity is lacking. The study investigates the copper and zinc levels in rat fetal liver to elucidate the different teratogenic expression of DPA, TETA, and dietary copper deficiency.
Data source
Reference
- Reference Type:
- publication
- Title:
- Molecular Localization of Copper and Zinc in Rat Fetal Liver in Dietary and Drug-induced Copper Deficiency
- Author:
- Keen, C.L., Cohen, N.L., Hurley, L.S., Lonnerdal, B.
- Year:
- 1 984
- Bibliographic source:
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 118, No. 3 Pages 697-703
Materials and methods
Test material
- Reference substance name:
- 3,6-diazaoctane-1,8-diamine tetrahydrochloride
- EC Number:
- 225-604-3
- EC Name:
- 3,6-diazaoctane-1,8-diamine tetrahydrochloride
- Cas Number:
- 4961-40-4
- Molecular formula:
- C6H18N4.4ClH
- IUPAC Name:
- N,N'-bis(2-aminoethyl)ethane-1,2-diamine tetrahydrochloride
Constituent 1
Results and discussion
Any other information on results incl. tables
There were no gross abnormalities in the fetuses of the control or copper deficient groups. For both DPA and TETA-fed groups, the frequency of abnormal fetuses increased with higher levels of drugs, but the pattern of abnormalities was quite different between the two drug groups.
Applicant's summary and conclusion
- Executive summary:
The teratogenicity of copper deficiency is well known, but underlying mechanisms have not been delineated. One method of studying the biochemical
lesions of copper deficiency is the use of chelating drugs with different chemical characteristics. The teratogenicity of a copper deficient diet and of diets containing either D-penicillamine or triethylenetetramine is quite different, although all three diets result in decreased fetal liver copper levels. Feeding D-penicillamine can result in decreased fetal liver zinc, while feeding triethylenetetramine can result in increased fetal liver zinc. The effect of
these three diets on fetal liver copper and zinc molecular localization was determined. Gel filtration showed that fetal liver copper and zinc in controls was localized in 3 fractions with MWs of > 50,000 (H), 30,000 ( I ) and 8 -10,000 (L) . Independent of dietary treatment, as liver copper diminished, copper was missing first from the L peak, then the I peak and with severe deficiency, from the H peak. Drug induced increases and decreases in fetal liver zinc were reflected in the L peak. These data suggest that the absolute levels of copper in the liver of the term fetus determines the distribution of the element among its binding ligands.
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