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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
LD50 oral:>5000 mg/kg bw (OECD 401)
LD50 dermal:>2000 mg/kg bw (OECD 402)
LD50 inhalation:>5 mg/L (OECD 403)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality observed
- Clinical signs:
- other: no clinical sign observed
- Body weight:
- other body weight observations
- Remarks:
- Body weight increased
- Gross pathology:
- No pathological changes were observed at necropsy.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Oral LD50 was greater than 5000 mg/kg bw for both mele and female Wistar rats.
- Executive summary:
In the acute oral toxicity study according to OECD TG 401, 10/sex/group of rats were administrated with test item (5000 mg/kg/bw) by oral gavage. No toxic signs were observed after application of test item, and no death occurred within two weeks.No pathological changes were observed at necropsy.Oral LD50 was greater than 5000 mg/kg bw for both male and female Wistar rats.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- > 5 000 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- not specified
- Test type:
- fixed concentration procedure
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Center of Experimental Animals,AMMS,Beijing
- Weight at study initiation: 180-220 g
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22-26°C
- Humidity (%): 40-60%
- Photoperiod (hrs dark / hrs light): 12/12
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- not specified
- Vehicle:
- water
- Mass median aerodynamic diameter (MMAD):
- < 1 µm
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Temperature:20-24℃
- Humidity:100%
- Air flow rate: 0.8 m3/hr
TEST ATMOSPHERE (if not tabulated)
- Particle size distribution: smaller than 1μm - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 5 h
- Concentrations:
- 5 mg/L
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes - Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 5 h
- Mortality:
- No animal died during the study.
- Clinical signs:
- other: No clinical signs observed during the study.
- Body weight:
- Body weight increased
- Gross pathology:
- No pathological changes were observed at necropsy.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The inhalation LC50 of test item was greater than 5 mg/L for both male and female Wistar rats.
- Executive summary:
In an acute inhalation toxicity study according to OECD TG 403, 10 male and 10 female Wistar rats were exposed to test item at the dose level of 5 mg/L for 5 hours and afterwards observed for 14 days after removal of the test item.No clinical toxic signs were observed after application of test item and no death occurred with two weeks.No pathological changes were observed at necropsy.Inhalation LD50 was determined as larger than 5 mg/L for both male and female Wistar rats.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- > 5 mg/L air
- Physical form:
- inhalation: aerosol
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Rationale for alternative/additional species to rat (if applicable)
- Source: Center of Experimental Animals, AMMS,Beijing
- Weight at study initiation: 180-220 g
- Acclimation period:5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-26°C
- Humidity (%): 40-60%
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light): 12/12
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 4 cm* 5 cm
REMOVAL OF TEST SUBSTANCE
- Washing (if done): washed away by soap and clean water
- Time after start of exposure:24 hours
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Clinical signs observation conducted - Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No death occured.
- Clinical signs:
- other: No toxic signs were observed.
- Body weight:
- other body weight observations
- Remarks:
- Body weight increased
- Gross pathology:
- No pathological changes were observed at necropsy.
- Other findings:
- - Organ weights:
- Histopathology:
- Potential target organs:
- Other observations: - Interpretation of results:
- GHS criteria not met
- Conclusions:
- Acute dermal LD50 was larger than 2000 mg/kg bw for both male and female Wistar rats.
- Executive summary:
In an acute dermal toxicity study according to OECD TG 402, 10 male and 10 female Wistar rats were exposed to test item at the dose level of 2000 mg/kg bw for 24 hours and afterwards observed for 14 days after removal of the test item.No clinical toxic signs were observed after application of test item and no death occurred with two weeks.No pathological changes were observed at necropsy.Dermal LD 50 was determined as larger than 2000 mg/kg bw for both male and female Wistar rats.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD100
- Value:
- > 2 000 mg/kg bw
Additional information
Acute Oral Toxicity
In the acute oral toxicity study according to OECD TG 401, 10/sex/group of rats were administrated with test item (5000 mg/kg/bw) by oral gavage. No toxic signs were observed after application of test item, and no death occurred within two weeks.No pathological changes were observed at necropsy.Oral LD50 was greater than 5000 mg/kg bw for both mle and female Wistar rats.
Acute Inhalation Toxicity
In an acute inhalation toxicity study according to OECD TG 403, 10 male and 10 female Wistar rats were exposed to test item at the dose level of 5 mg/L for 5 hours and afterwards observed for 14 days after removal of the test item.No clinical toxic signs were observed after application of test item and no death occurred with two weeks.No pathological changes were observed at necropsy.Inhalation LD50 was determined as larger than 5 mg/L for both male and female Wistar rats.
Acute Dermal Toxicity
In an acute dermal toxicity study according to OECD TG 402, 10 male and 10 female Wistar rats were exposed to test item at the dose level of 2000 mg/kg bw for 24 hours and afterwards observed for 14 days after removal of the test item.No clinial toxic signs were observed after application of test item and no death occurred with two weeks.No pathological changes were observed at necropsy.Dermal LD 50 was determined as larger than 2000 mg/kg bw for both male and female Wistar rats.
Justification for classification or non-classification
Based on the available information in the dossier, the substance Reaction product of 2-hydroxybenzoic acid, styrene and oxozinc does not need to be classified for acute toxicity or specific target organ toxicity — single exposure when the criteria outlined in CLP Regulation (Annex I of 1272/2008/EC) are applied.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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