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EC number: 856-079-4 | CAS number: 55860-35-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EUR 20268
- Version / remarks:
- European Commission Technical Guidance Document EUR 20268, Determination of particle size distribution, fibre length and diameter distribution of chemical substances (2002)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- cascade impaction
- Type of particle tested:
- primary particle
- Type of distribution:
- mass based distribution
Test material
- Reference substance name:
- 4-acetyl-2-methylbenzoic acid
- EC Number:
- 856-079-4
- Cas Number:
- 55860-35-0
- Molecular formula:
- C10H10O3
- IUPAC Name:
- 4-acetyl-2-methylbenzoic acid
- Test material form:
- solid: particulate/powder
Constituent 1
Results and discussion
- Mass median aerodynamic diameter:
- 4.08 µm
- Geometric standard deviation:
- 2.66
Particle size
- Percentile:
- other: MMAD
- Mean:
- 4.08 µm
- St. dev.:
- 2.66
Particle size distribution at different passagesopen allclose all
- No.:
- #1
- Size:
- 10.4 µm
- Distribution:
- 90.6 %
- Remarks on result:
- other: Cumulative amount less than indicated size
- No.:
- #2
- Size:
- 7.7 µm
- Distribution:
- 66.2 %
- Remarks on result:
- other: Cumulative amount less than indicated size
- No.:
- #3
- Size:
- 4.1 µm
- Distribution:
- 33.8 %
- Remarks on result:
- other: Cumulative amount less than indicated size
- No.:
- #4
- Size:
- 1.3 µm
- Distribution:
- 10.8 %
- Remarks on result:
- other: Cumulative amount less than indicated size
- No.:
- #5
- Size:
- 0.9 µm
- Distribution:
- 6.5 %
- Remarks on result:
- other: Cumulative amount less than indicated size
- No.:
- #6
- Size:
- 0.56 µm
- Distribution:
- 4.3 %
- Remarks on result:
- other: Cumulative amount less than indicated size
Any other information on results incl. tables
A preliminary evaluation of the substance was performed by sieve analysis using an Inclyno sieve shaker. 26.3% passed through a 100 µm sieve after a 33 minute period. The use of a sieve brushing technique to eliminate the influence of aggregation of the substance demonstrated that an aliquot of test substance passed completely through a 100 µm sieve, with no visible residue retained.
Therefore, definitive quantification was performed by cascade impactor analysis. A dust atmosphere was produced from the test substance using a SAG 410 Solid Aerosol Generator (TOPAS GmbH, Dresden, Germany) located adjacent to the atmosphere chamber and connected to a metered compressed air supply. The compressed air was supplied by means of an oil free compressor and passed through a water trap and respiratory quality filter before it was introduced to the aerosol generator. The cylindrical atmosphere chamber had a volume of about 30 L. The aerosol concentration in the chamber was measured at the time of atmosphere generation with a gravimetric method using glass fiber filters placed in a holder, and the actual measured concentrations were 2.06 and 3.14 mg/L. The particle size distribution of the test substance aerosol in the chamber was then determined in duplicate using a Marple Personal Cascade Impactor, consisting of a series of impactor stages with stainless steel collection substrates and a backup glass fibre filter housed in an aluminium sampler. The sampler was temporarily sealed in a sampling port in the chamber and a suitable, known volume of atmosphere chamber air was drawn through it using a vacuum pump. The collection substrate and backup filters were weighed before and after sampling and thw weight of test item, collected at each stage was calculated by difference.
The mass median aerodynamic diameter (MMAD) was calculated to be 4.08 µm. The geometric standard deviation was calculated to be 2.66 µm.
Applicant's summary and conclusion
- Conclusions:
- The MMAD of the substance as determined by cascade impactor analysis was 4.08 µm and the geometric standard deviation was 2.66 µm.
- Executive summary:
The particle size distribution of the substance was studied under GLP to European Commission Guidance Document EUR 20268, Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances (2002).
A preliminary evaluation of the substance was performed by sieve analysis using an Inclyno sieve shaker. 26.3% passed through a 100 µm sieve after a 33 minute period. The use of a sieve brushing technique to eliminate the influence of aggregation of the substance demonstrated that an aliquot of test substance passed completely through a 100 µm sieve, with no visible residue retained.
Therefore, definitive quantification was performed by cascade impactor analysis. A dust atmosphere was produced from the test substance using a SAG 410 Solid Aerosol Generator (TOPAS GmbH, Dresden, Germany) located adjacent to the atmosphere chamber and connected to a metered compressed air supply. The compressed air was supplied by means of an oil free compressor and passed through a water trap and respiratory quality filter before it was introduced to the aerosol generator. The cylindrical atmosphere chamber had a volume of about 30 L. The aerosol concentration in the chamber was measured at the time of atmosphere generation with a gravimetric method using glass fiber filters placed in a holder, and the actual measured concentrations were 2.06 and 3.14 mg/L. The particle size distribution of the test substance aerosol in the chamber was then determined in duplicate using a Marple Personal Cascade Impactor, consisting of a series of impactor stages with stainless steel collection substrates and a backup glass fibre filter housed in an aluminium sampler. The sampler was temporarily sealed in a sampling port in the chamber and a suitable, known volume of atmosphere chamber air was drawn through it using a vacuum pump. The collection substrate and backup filters were weighed before and after sampling and thw weight of test item, collected at each stage was calculated by difference.
The mass median aerodynamic diameter (MMAD) was calculated to be 4.08 µm. The geometric standard deviation was calculated to be 2.66 µm.
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