1H-Isoindole-1,3(2H)-dione, 2-[(6,11-dihydro-5H-dibenz[b,e]azepin-6-yl)methyl]-

Endpoint summary

Description of key information

The acute oral LD50 of the substance was predicted to be 1689.28 mg/kg; however, the reliability of that prediction shows strong restrictions.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

(Q)SAR

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification

Justification for type of information:

The reliability assessment of the prediction is shown in the attached document (QPRF).

Qualifier:

equivalent or similar to guideline

Guideline:

other: ECHA guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals.

Specific details on test material used for the study:

C1C2=CC=CC=C2C(NC3=CC=CC=C31)CN4C(=O)C5=CC=CC=C5C4=O

Dose descriptor:

LD50

Effect level:

ca. 1 689.28 other: mg/kg

The prediction was deemed to be reliable with restrictions on the basis of the parameters listed above. The molecule might fall into the applicability domain of the model.

Interpretation of results:

study cannot be used for classification

Conclusions:

The acute oral LD50 of the substance was predicted to be 1689.28 mg/kg; however, the reliability of that prediction shows strong restrictions.

Justification for classification or non-classification

Due to low reliability of the predictions, data available are deemed to be inconclusive. Overall, the substance should not be classified for acute oral toxicity.

No data are available for acute dermal toxicity and acute inhalation toxicity.