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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2019-2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Version / remarks:
- 2008
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable.
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Inspected on 15-16/11/2017, Signed on 15/05/2018
- Type of method:
- capillary method
- Key result
- Melting / freezing pt.:
- >= -11 - <= 1.6 °C
- Decomposition:
- no
- Sublimation:
- no
- Remarks on result:
- other: pressure not specified
- Conclusions:
- A freezing point was determined with–35.4 °C (237.8 K). A melting range was determined as-11.0 °C – 1.6 °C (262.2 to 274.8 K).
- Executive summary:
An experimental study, conducted in accordance with conditions recommended in OECD guideline and under GLP was performed. The DSC- pre-test for determination of the freezing/melting point yield no reliable results.
Therefore, the determinations were performed with the other methods.
The determination of the freezing point of the test item was determined with the Manual method. A freezing point was determined with–35.4 °C (237.8 K).
These values are the means of two independent determinations. The determination of the melting point of the test item was determined with the Capillary method.
A melting range was determined as-11.0 °C – 1.6 °C (262.2 to 274.8 K).
These values are the means of two independent determinations
As the test item is a liquid viscous UVCB substance it is not unusual that the DSC measurement could not find a reliable result. Often more energy is necessary as the DSC instrument can deliver to release the process of phase transition.
Anyway, no observations were made which might cause doubts on the validity of the study outcome. Therefore, the result of the study is considered valid.
Reference
DSC Method
Pre-Test DSC
No event could be detected, the monitor was informed and the determinationof the freezing/melting point was conducted with the other methods.
Freezing Point Manual Method
Pre-Test Freezing Point
Values Pre-test Freezing Point
Subject |
Temperature Test Item |
Temperature Cooling Bath |
Start of determination |
22.6 °C |
19.9 °C |
Freezing Point |
-35.5 °C |
-40.8 °C |
Observations test item:
- Since 5 °C test item became very viscous, the resistance became stronger on the wire sling
- Since 0 °C hardly possible to stir the wire sling, thereforethe temperature was observed without stirring, additionallythe surface of the test item was proved with a glass rod
- Since -20 °C test item started to get solid
- Since -35.5 °C solid like ice
Determination of the Freezing Point
Values Main Test Freezing Point – performed on 01. Apr. 2020
SubjectFirst determination |
Temperature Test Item |
Temperature Cooling Bath |
Start of determination |
21.3 °C |
-40.7 °C |
Freezing Point |
-35.3 °C |
-40.6 °C |
Subject Second determination |
Temperature Test Item |
Temperature Cooling Bath |
Start of determination |
21.4 °C |
-40.8 °C |
Freezing Point |
-35.4 °C |
-40.9 °C |
The observations were made like in the pre-test for freezing point.
Melting Point Capillary Method
The following values were recorded:
Values performed on 03. – 04. Apr. 2020
Melting range |
Begin |
End |
First Determination |
-10.9 °C (262.3 K) |
1.7 °C (274.9 K) |
Second Determination |
-11.1°C (262.1 K) |
1.5 °C (274.7 K) |
Evaluationand Result
Freezing Point
The value of the mean was calculated as:
-35.4 ± 0.1 °C (237.8 ± 0.1 K)
Melting Point
The means between both determinations give the following values for the melting range:
Melting range: -11.0 to 1.6 °C (262.2 to 274.8 K)
Standard deviation: 0.14 (begin); 0.14 (end)
Estimated accuracy: ± 0.2 °C
2 Validity
2.1 Freezing Point
As the difference between the two values was found with 0.1 °C the validity criteria were met.
2.2 Melting Point
All validity criteria are presented in the following table.
Table 10.2‑a Validity melting point
Parameter |
Criterion |
Found |
Assessment |
Difference between duplicate determinations |
£0.5 K |
0.2 K |
valid |
Difference between begin and end of melting process |
£0.5 K |
12.6 K |
melting range was stated |
Description of key information
A freezing point was determined with –35.4 °C (237.8 K). A melting range was determined as-11.0 °C – 1.6 °C (262.2 to 274.8 K).
Key value for chemical safety assessment
Additional information
An experimental study, conducted in accordance with conditions recommended in OECD guideline and under GLP, was performed. It should be considered as a key study. The result should be retained as key data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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