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EC number: 269-198-6 | CAS number: 68189-42-4
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 7-18 September 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
- Version / remarks:
- 1981
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- ISO 13320 (Particle size analysis - Laser diffraction methods)
- Version / remarks:
- 2009
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7520 (Particle Size, Fiber Length, and Diameter Distribution)
- Version / remarks:
- 1996
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- Laser scattering/diffraction
- Type of distribution:
- volumetric distribution
Test material
- Reference substance name:
- Methanol
- EC Number:
- 200-659-6
- EC Name:
- Methanol
- Cas Number:
- 67-56-1
- Molecular formula:
- CH4O
- IUPAC Name:
- methanol
- Reference substance name:
- Acetone
- EC Number:
- 200-662-2
- EC Name:
- Acetone
- Cas Number:
- 67-64-1
- Molecular formula:
- C3H6O
- IUPAC Name:
- acetone
- Reference substance name:
- Water
- EC Number:
- 231-791-2
- EC Name:
- Water
- Cas Number:
- 7732-18-5
- Molecular formula:
- H2O
- IUPAC Name:
- Oxidane
- Reference substance name:
- p-nitrophenyl dihydrogen phosphate, compound with 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:2)
- EC Number:
- 269-198-6
- EC Name:
- p-nitrophenyl dihydrogen phosphate, compound with 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:2)
- Cas Number:
- 68189-42-4
- Molecular formula:
- C6H6NO6P.2C4H11NO3
- IUPAC Name:
- 4-nitrophenyl dihydrogen phosphate - 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:2)
- Test material form:
- solid
- Details on test material:
- Batch / Lot No. 46587100
impurity 1
impurity 2
impurity 3
Constituent 1
- Specific details on test material used for the study:
- Batch No.: 46587100
Storage: Refrigerator (approx. 2-8°C)
Results and discussion
Particle sizeopen allclose all
- Key result
- Percentile:
- D50
- Mean:
- 12.2 µm
- St. dev.:
- 0.96
- Percentile:
- D10
- Mean:
- >= 2.3 - <= 2.4 µm
- St. dev.:
- 0.053
- Percentile:
- D90
- Mean:
- >= 48 - <= 62.2 µm
- St. dev.:
- 6.32
Any other information on results incl. tables
Light Microscopy
The optically investigation of the test item with different magnifications has been investigated. For a better visualization a 10x10 grid with 100 µm squares was used. At 5x and 20x magnifications bigger agglomerates can be observed. Examining the 50x magnification, the test item consists of crystalline particles.
Particle size distribution
Two test series of 3 measurements each were performed with the fine fraction of the test item.
Test series 1:
| Percentile | Particle size (µm) | Standard deviation |
| D10 | 2.3 | 0.07 |
| D50 | 12.1 | 0.39 |
| D90 | 48.0 | 3.50 |
Test series 2:
| Percentile | Particle size (µm) | Standard deviation |
| D10 | 2.4 | 0.08 |
| D50 | 12.3 | 0.49 |
| D90 | 62.2 | 8.34 |
Applicant's summary and conclusion
- Conclusions:
- The test item 4-NPP, di-TRIS (CAS no. 68189-42-4) has a median particle size of D50 = 12.2 µm, which was determined by laser diffraction measurement according to OECD Test Guideline 110 (1981), ISO 13320 (2009) and EPA OCSPP Test Guideline OPPTS 830.7520 (1996).
- Executive summary:
The test item 4-NPP, di-TRIS (CAS no. 68189-42-4) has a median particle size of D50 = 12.2 µm, which was determined by laser diffraction measurement according to OECD Test Guideline 110 (1981), ISO 13320 (2009) and EPA OCSPP Test Guideline OPPTS 830.7520 (1996).
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