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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 March 2020 - 14 July 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: Method A5 Surface Tension of Commission Regulation (EC) No 440/2008
- Version / remarks:
- 30 May 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Method 115 of the OECD Guidelines for the Testing of Chemicals
- Version / remarks:
- 27 July 1995
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- other: ring method - critical micelle concentration
- Key result
- Water solubility:
- 288 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- >= 5.1 - <= 6.8
- Conclusions:
- The critical micelle concentration of the test item was determined to be 288 mg/L at 20.0 ± 0.5 °C. The water solubility of a surfactant may be expressed in terms of the CMC.
- Executive summary:
The ciritcal micelle concentration was determined to be 288 mg/L at 20.0 ± 0.5 °C, by determining the surface tension of a range of aqueous sample solutions of differing concentration, using a procedure based on Method A.5 Surface Tension of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 115 of the OECD Guidelines for Testing of Chemicals, 27 July 1995. Study was conducted under GLP conditions.
Reference
The readings and temperatures for the sample solutions are reported in Table 8 in the attached background material.
The concentration (mg/L), log10 [concentration (mg/L)] and mean surface tension values for the sample solutions are shown in the following table:
Table 9 - Concentration (mg/L), log10[concentration (mg/L)] and mean surface tension values
Concentration (mg/L) | Log10 Concentration | Mean Surface Tension (mN/m) | Solution pH |
3.01 x 10^4 | 4.48 | 29.0 | 5.1 |
1.00 x 10^4 | 4.00 | 29.5 | 6.2 |
3.01 x 10^3 | 3.48 | 30.0 | 6.4 |
1.00 x 10^3 | 3.00 | 31.0 | 6.6 |
301 | 2.48 | 32.5 | 6.8 |
181 | 2.26 | 39.5 | 6.5 |
100 | 2.00 | 50.2 | 6.4 |
30.1 | 1.48 | 57.0 | 6.3 |
10 | 1.00 | 63.0 | 6.3 |
1 | 1.73 x 10-3 | 70.0 | 6.3 |
The plot of log10 [concentration (mg/L)] versus surface tension (mN/m) is shown in Figure 3 (attached).
Line 1 (red) was generated from linear regression of 2 sample solution concentrations for which the surface tension was shown to be concentration dependent and Line 2 (green) was generated from linear regression of 3 sample solution concentrations for which the surface tension was observed to be essentially independent of concentration. The intersection of these two lines gave the critical micelle concentration and was calculated by solving the two equations:
Line 1 equation: y = -41.9x + 134
Line 2 equation: y = -0.999x + 33.5
The sample solution at 1.00 x 10^3 and 301 mg/L were not used in generating the two lines. At this concentration the surface tension appeared to be transitioning to Line 2 at a shallower gradient than Line 1.
The sample solutions at 30.1, 10.0 and 1.00 mg/L were not used in generating the two lines. At this concentration the surface tension was approaching that of purified water.
The CMC was determined to be 288 mg/L.
Discussion
The critical micelle concentration (CMC) is an important characteristic of a surfactant. At low concentrations of surfactant, the surface tension of water is only slightly affected. Increasing the concentration but before reaching the CMC, the surface tension changes significantly. After reaching the CMC and above, the surface tension remains relatively constant or changes with a much more gradual slope.
Below the CMC, a surfactant is considered to be thermodynamically soluble in the water; whereas above the CMC, the solubility of a surfactant in water has been exceeded and the excess surfactant aggregates to form micelles. These micelles have significantly less effect on the surface tension of a solution and are considered not to be in solution. Thus, the water solubility of a surfactant may be expressed in terms of the CMC.
Description of key information
The critical micelle concentration of the test item was determined to be 288 mg/L at 20.0 ± 0.5 °C. The water solubility of a surfactant may be expressed in terms of the CMC.
Key value for chemical safety assessment
Additional information
The ciritcal micelle concentration was determined to be 288 mg/L at 20.0 ± 0.5 °C, by determining the surface tension of a range of aqueous sample solutions of differing concentration, using a procedure based on Method A.5 Surface Tension of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 115 of the OECD Guidelines for Testing of Chemicals, 27 July 1995. Study was conducted under GLP standards.
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