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EC number: 255-256-8 | CAS number: 41199-19-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 4-(2,6,6-trimethyl-2-cyclohexen-1-yl)butan-2-one
- EC Number:
- 250-657-4
- EC Name:
- 4-(2,6,6-trimethyl-2-cyclohexen-1-yl)butan-2-one
- Cas Number:
- 31499-72-6
- Molecular formula:
- C13H22O
- IUPAC Name:
- 4-(2,6,6-trimethylcyclohex-2-en-1-yl)butan-2-one
- Reference substance name:
- 1,2,3,4,4a,5,6,7-octahydro-2,5,5-trimethyl-2-naphthol
- EC Number:
- 255-256-8
- EC Name:
- 1,2,3,4,4a,5,6,7-octahydro-2,5,5-trimethyl-2-naphthol
- Cas Number:
- 41199-19-3
- Molecular formula:
- C13H22O
- IUPAC Name:
- 2,5,5-trimethyl-1,2,3,4,4a,5,6,7-octahydronaphthalen-2-ol
- Test material form:
- liquid
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River (UK) Limited, Margate Kent
- Age at study initiation: 5-7 weeks
- Weight at study initiation: Male: 111-128 g; Females 121-130 g
- Fasting period before study: overnight
- Housing: 5 per cage per sex in grid bottomed cages
- Diet: Pelleted diet (SQC Rat and Mouse Maintenance Diet No. 1 Expanded, produced by Special Diets Services, Witham, Essex, ad libitum
- Water: ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18-22
- Humidity (%): 47-65
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 15 days
- Frequency of observations and weighing: The rats were observed approximately 30 minutes, 1, 2, and 4 hours after dosing and once daily for consecutive 14 days. On the day of dosing, all animals were weighed. They were weighed again on day 8 and day 15.
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Four hours after dosing, 2 females were found to be hypoactive and ataxic. Breathing was slow in both animals and one animal was laterally recumbent. One hour and twenty minutes later both animals were prostrate with eyes half closed, exhibiting slight piloerection, red/black bilateral
periorbital staining and were suffering tremors. At this point they were killed. - Clinical signs:
- other: Clinical signs observed in the surviving animals were mild and of short duration, most animals recovering within 24 hours of dosing. The following effects were observed - Male 1: No effects - Male 2: Hypoactivity at 4 hours - Male 3: Hypoactivity at 4 hou
- Gross pathology:
- The necropsy findings were considered to be either due to agonal changes or to be consistent with the background macroscopic pathology of this strain of rat.
- Male 1: Enlarged submandibular lymph nodes
- Male 2: No abnormalities detected
- Male 3: Enlarged submandibular lymph nodes. Moderate pelvic dilation in the right kidney. Minimal pelvic dilation in the left kidney.
- Male 4: Enlarged submandibular lymph nodes.
- Male 5: Lungs appeared reddened and did not collapse when thorax was opened.
- Female 1: Moderately distended uterus with fluid
- Female 2: No abnormalities detected
- Female 3: Distended stomach with brown/yellow oily material. Moderately distended uterus with fluid.
- Female 4: Enlarged submandibular lymph nodes
- Female 5: Distended stomach with brown/yellow oily material.
Applicant's summary and conclusion
- Interpretation of results:
- other: not acute harmful
- Remarks:
- according to EU CLP (EC 1272/2008 and its amendments)
- Conclusions:
- The substance has an LD50 of >2000 mg/kg bw in a OECD TG 401 study.
- Executive summary:
The acute oral toxicity has been studied in an OECD TG 401 test following GLP principles. The substance was administered at a dose of 2000 mg/kg bw to 5 male and 5 female SD rats and animals were observed for 14 days. Two females were found to be hypoactive, ataxic and suffering tremors 5.5 hours after dosing and were killed in extremis. In the surviving animals, clinical signs were limited to brown peribuccal staining in 3 animals 30 minutes after dosing and hypoactivity in all animals 4 hours after dosing. Generally recovery had occurred by day 2. There were no adverse effects an bodyweight gain in animals of either sex. There were no treatment related necropsy findings. The acute oral toxicity (LD50) was determined to be >2000 mg/kg.
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