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EC number: 931-371-5 | CAS number: 171171-80-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986-10-06 to 1987-01-10
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment. Combined study report, hence some detail issues.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Limit test:
- yes
Test material
- Reference substance name:
- Magnesium, bis(2-hydroxybenzoato-O1,O2)-, ar,ar'-di-C14-18alkyl derivs.
- EC Number:
- 931-371-5
- Cas Number:
- 171171-80-5
- IUPAC Name:
- Magnesium, bis(2-hydroxybenzoato-O1,O2)-, ar,ar'-di-C14-18alkyl derivs.
- Details on test material:
- - Name of test material (as cited in study report): [CAS Number 171171-80-5]
- Physical state: Dark brown viscous liquid
- Lot/batch No.: XSA 053J
- Storage condition of test material: In the dark at ambient temperature
- Stability under test conditions: Infra-red spectra taken on 14 August 1986 and 18 December 1986 showed no differences and the substance was judged to have been stable for the duration of the study
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River UK Ltd
- Age at study initiation: 9-11 weeks
- Weight at study initiation: 208-224 g (males) and 135-155 g (females)
- Fasting period before study: overnight (18 h)
- Housing: On arrival, animals were housed in single sex groups of up to 12 in a cage with each cage measuring 56 cm x 38 cm x 18 cm. The animals were quarantined in non-barried animal rooms with access restricted to essential personnel. Prior to experimentation, the animals were rehoused (as single sex groups of four) in cages with stainless steel wire-mesh floors and tops; each cage measuring 38 cm x 25 cm x 18 cm. The cages were mounted in five rows of four on both sides of a double-sided rack (a total of 40 cages). Paper-lined trays for excreta were placed beneath each cage.
- Diet: PRG, Labsure Animal Foods, Dorset ad libitum by means of a top loading food hopper (except during the 24 hours after dosing)
- Water: Filtered but untreated water from the public supply ad libitum by means of an automatic valve-regulated drinking line
- Acclimation period: = 7 days
ENVIRONMENTAL CONDITIONS
- Temperature: 19-25 degrees Centigrade
- Photoperiod: Automatically controlled cycle of light (06:00 to 18:00) and dark (18:00 to 06:00)
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The day before dosing (day zero) approximately 60 % of the dorsal hair of all animals was closely shorn with fine electric clippers. Immediately before application of the test material, the skin was visually inspected to ensure that all micro-abrasions of the stratum corneum had healed. The calculated dose was applied to the shorn skin at room temperature by syringe, the dose being altered by varying the volume dispensed from the syringe. The test material was covered with a piece of aluminium foil lined with gauze and the foil held in place by a double overwrap of waterproof adhesive tape.
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- Five males and five females
- Control animals:
- no
- Details on study design:
- At least two days before dosing, the rats to be used were housed in groups of two or three animals of the same sex per cage and each animal individually earmarked. The animals were weighed on the day of dosing (day 1). The rats were individually housed for 24 hours after dosing, with food withheld but water available ad libitum. At the end of the 24 h exposure period, the tape and foil were carefully removed and the skin washed with warm dilute detergent solution and then dried. The animals were then returned to group housing. The animals were observed for signs of toxicity for 14 days after dosing. Observations were recorded up to three times a day during the first three days and daily thereafter. Initial (day 1), day 7 and day 14 body weights were recorded.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: maximum dose that could be applied
- Mortality:
- None of the rats died
- Clinical signs:
- other: Inflamation of the treated site (see Tables 1 and 2, attached)
Applicant's summary and conclusion
- Conclusions:
- The acute percutaneous LD50 of the undiluted test substance was greater than 2000 mg/kg, the maximum dose that could be applied.
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