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EC number: 201-126-0 | CAS number: 78-59-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The substance with high probability acutely not harmful to aquatic invertebrates.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 224 mg/L
Additional information
Experimental data are available for the assessment of the short-term toxicity of isophorone to aquatic invertebrates. Under supervision of the Japanese Ministry of the Environment an acute daphnia test according to OECD 202 was conducted under GLP and published in 1996. The test species was Daphnia magna. The 48-h EC50 was determined to be 224 mg/L (nominal, NITE, 1996).
In addition, the substance was tested in a static short-term toxicity test with Daphnia magna as a test organism in the publication of Le Blanc (1980). The study was conducted according to the methods of US EPA, EPA-660/3-75-009 (1975). The 48-h EC50 was determined to be 120 mg/L (nominal, Le Blanc, 1980). The EC50 value in the publication of Le Blanc (1980) appears to be more sensitive than the EC50 value in the OECD 202 study from NITE (1996). However, in the publication of Le Blanc the procedures are reported but not assigned to substances itself, therefore, it is not clear if the vehicle was used in this study. Thus, it is not clear if the toxicity of the substance can be due to vehicle. Therefore, the 48-h EC50 value from the GLP OECD 202 study are considered as a key value for the assessment of isophorone (CAS 78-59-1).
In both studies the test concentrations were not analytically verified. However, the stability of the substance was analytically verified in various ecotoxicity studies with fish (Cairns and Nebeker, NITE, see IUCLID Ch. 6.1.1) and in a study with algae (NITE, see IUCLID Ch. 6.1.5). Moreover, the substance appeared to be stable during endocrine studies (see IUCLID Ch. 6.1.8).
Overall, it can be concluded that the substance with high probability acutely not harmful to aquatic invertebrates.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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