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EC number: 806-451-7 | CAS number: 42532-60-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The parent was not tested for technical reasons (hydrolytic instability). 72-hr EC50, growth rate, of the hydrolysis product: >100 mg/L (nominal) (OECD 201). 72-hour NOEC, 10 mg/L.
Key value for chemical safety assessment
Additional information
C4 fluorinated isonitrile is gas which, to the extent it dissolves in water, is hydrolytically unstable. We have proposed adaptation of the testing requirement for toxicity to aquatic algae and cyanobacteria, substituting direct testing of the hydrolysis product. The key study, with Pseudokirchneriella subcapitata, was conducted as per guideline OECD 201 with analytical confirmation of the tested dose. Since measured concentrations were within 80% of nominal, the results were reported on a nominal concentration basis. The 72-hour EC50 of the heptafluoroisobutyramide hydrolysis product was >100 mg/L, the highest concentration tested. The 72-hour NOEC was 10 mg/L based on a statistically but not biologically significant 6% inhibition of growth rate at 100 mg/L. In a supporting, non-guideline study with Pseudokirchneriella subcapitata, the 72-hour NOEC (biomass) of the hydrolysis product was 100 mg/L (nominal concentration, highest tested).
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