3,4-xylenol

Biodegradation in water: screening tests

Administrative data

Endpoint:

biodegradation in water: screening test, other

Type of information:

(Q)SAR

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

Proposed criterion (USEPA 2004) for an overall YES or NO Ready Biodegradability prediction are as follows: If Biowin 3 (ultimate survey model) result is "weeks" or faster (e.g. days or days to weeks) ≥ 2.75 AND Biowin5 (MITI linear model) ≥ 0.5, then the prediction is YES

Data source

Reference

Title:

EPI Suite Version 4.11

Year:

2012

Bibliographic source:

BIOWIN v4.10 - Biowin3

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: REACH Guidance Chapter R.6: QSARs and grouping of chemicals

Version / remarks:

May 2008

Test material

Test material information

Constituent 1

Reference substance name:

3,4-xylenol

EC Number:

202-439-5

EC Name:

3,4-xylenol

Cas Number:

95-65-8

Molecular formula:

C8H10O

IUPAC Name:

3,4-dimethylphenol

Results and discussion

% Degradation

Remarks on result:

readily biodegradable based on QSAR/QSPR prediction

Applicant's summary and conclusion

Interpretation of results:

not readily biodegradable

Conclusions:

The prediction of BIOWIN3 in combination with BIOWIN5 is not readily biodegradable but the result is borderline.