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EC number: 446-810-1 | CAS number: 136239-66-2 1-BUTOXY-2,3-DIFLUORBENZOL; BUPHOL
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14 JAN 2002 - 15 MAY 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- Guideline 92/69/EEC, 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Water solubility:
- 2.8 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 5.9
- Conclusions:
- The water solubility of the test item at a temperature of 20°C is 2.8 mg/L.
- Executive summary:
The water solubility of the test item was tested according to EU Method A.6 and OECD Guideline 105 in a GLP study via the column-elution method. The water solubility of the test item at a temperature of 20°C is 2.8 mg/L.
Reference
Preliminary Visual Estimation of the Water Solubility
The preliminary visual experiments showed that the water solubility of the test substance is between 10 and 20 mg/L. Therefore the water solubility had to be determined by the "flask-method", but due to the arguments mentioned in chapter (Preliminary visual estimation of the water solubility) the column-elution-method was used.
Column elution method
The coating check was successful.
According to the guideline, the data of the fractions 1 to 5 were not take into account for the following evaluation. The values for the water solubility were calculated from the fractions 14 to 18 for column 5, from fractions 7 to 12 without 10 for column 6 and from fractions 25 to 29 for column 3.
Fractions 6 to 13 for column 5, fractions 6 and 10 for column 6 and fractions 6 to 24 and 30 to the end for column 3 were discarded.
Result run 3: Evaluation of the fractions 25 to 29. The measured concentration in a 0.5-1 mL dilution was found to be < 0.05 mg/L.
Result run 5: Evaluation of the fractions 14 to 18. The water solubility was found to be 2.94 mg/L.
Result run 6: Evaluation of the fractions 7 to 12 - without 10. The water solubility was found to be 2.71 mg/L.
Description of key information
The water solubility of the test item was tested according to EU Method A.6 and OECD Guideline 105 in a GLP study via the column-elution method. The water solubility of the test item at a temperature of 20°C is 2.8 mg/L.
Key value for chemical safety assessment
- Water solubility:
- 2.8 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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