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Diss Factsheets
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EC number: 478-900-1 | CAS number: 6156-18-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
2,2 -bis(methylthio)propane was considered to be stable at pH 7 and pH 9. But at pH4 and 1.2, it was found to be hydrolytically unstable. The half-lives at pH4 were respectively 133, 701, 1868 (estimation) and 5373 hours for the temperatures 50, 37, 25 and 15°C. At pH 1.2 and 37°C, a half-life of 1.21h was found.
Key value for chemical safety assessment
Additional information
The hydrolysis at pH 4, 7 and 9 of 2,2 -bis(methylthio)propane was determined in a test performed according to OECD 111 and GLP requirements (Gancet, 2008).The preliminary test showed that the item was unstable at pH 4 and 50°C but stable at pH 7 and 9. Acetone and methyl-mercaptan, the decomposition products of 2,2-Bis(methylthio)propane were detected by the analysis. A definitive test was conducted at pH4 and at 3 temperatures: 15, 37 and 50°C. Hydrolysis of the test item (100 mg/L solution) was conducted in order to obtain an hydrolysis rate between 20 and 70 %. At 50°C, these conditions were observed within 13 days (76% of hydrolysis). For the other temperatures, after 28 days, only 50% of the test item was hydrolysed at 37°C and 7% at 15°C. The results of this test indicated pseudo-first order kinetics. The half-lives at pH4 were respectively 133, 701, 1868 (estimation) and 5373 hours for the temperatures 50, 37, 25 and 15°C. The test was considered to be valid.
In addition, the hydrolysis at pH 1.2 and 37°C of 2,2 -bis(methylthio)propane was determined in a test performed according to OECD 111 and GLP requirements (Gancet, 2009). The preliminary test showed that the item was unstable at pH 1.2 and 37 °C. Acetone and methyl-mercaptan, the decomposition products of the test substance were detected by the analysis. A definitive test was conducted at pH 1.2 and at 37 °C. Hydrolysis of the test item (160 mg/L solution) was conducted in order to obtain an hydrolysis rate between 20 and 70 %. The test substance was unstable at pH 1.2 and 37°C with a half-life of 1.21h. Acetone and methyl mercaptan were identified as decomposition products. The test was considered to be valid.
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