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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14th January 1993 to 18th May 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 123 (Partition Coefficient (1-Octanol / Water), Slow-Stirring Method)
- Deviations:
- not applicable
- Remarks:
- The study pre-dates the inception of the standard testing guideline, but follows the core principles of the test.
- Principles of method if other than guideline:
- The study pre-dates the introduction of the HPLC method. As the shake flask method
The test method does not conform to OECD 117 or OECD 108 (EU Method A.8) due to the solubility, the relevant analytical methods and the emulsification properties of the test material, which makes it unsuitable for evaluation using the above standard test methods. The study pre-dates the introduction of
Briefly the partition coefficient of the test material was estimated and volume ratios of the two solvents, 1:100, 1:50 and 1:200 octan-1-ol:water were prepared.
A stock solution of the test material in octan-1-ol saturated water was prepared and replicate aliquots of this were used to prepare the test mixtures. Experience with the test material in evaluating the water solubility indicated that the test material formed a stable emulsion. Further evaluations investigating the fat solubility of the test material indicated that in organic media, the test material was found to be miscible. These solutions were slowly stirred for approximately 40 hours at 20 °C and then allowed to separate. After separation, the pH of each aqueous phase was measured and the two component phases of each test mixture were analysed for the test material by derivatisation and HPLC. - GLP compliance:
- yes
- Type of method:
- slow-stirring method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 3.69
- Temp.:
- 20 °C
- pH:
- 6.4
- Conclusions:
- The partition coefficent of the test material was determined to be log Pow 3.69 at 20 °C.
- Executive summary:
The partition coefficient of the test material was determined in accordance with a method similar to the slow stirring method. Under the conditions of the test, the partition coefficent of the test material was determined to be log Pow 3.69 at 20 °C.
Reference
Table 1: Results
Sample |
Volume ratio |
Vw |
Vo |
Cw (mg/L) |
Co (mg/L) |
Pow |
Log Pow |
Recovery (mg) |
pH |
1 |
1:100 |
1000 |
10 |
4.900 |
550 |
112 |
2.05* |
10.4 |
6.08 |
2 |
1000 |
10 |
0.116 |
583 |
5013 |
3.70 |
5.95 |
6.25 |
|
3 |
1:200 |
1000 |
20 |
0.073 |
161 |
2205 |
3.34 |
3.29 |
6.31 |
4 |
1000 |
20 |
0.030 |
220 |
7261 |
3.386 |
4.43 |
6.42 |
|
5 |
1:50 |
1000 |
5 |
0.072 |
497 |
6912 |
3.84 |
2.56 |
6.48 |
6 |
1000 |
5 |
0.009 |
388 |
43596 |
4.46* |
1.95 |
6.45 |
Where Vw = Volume of water saturated with octanol
Vo = Volume of octanol saturated with water
Cw = Concentration of test material in water saturated with octanol
Co = Concentration of test material in octanol saturated with water
* Data not used in calculation
Mean Pow at VR = 1:100 = 5013
Mean Pow at VR = 1:200 = 4733
Mean Pow at VR = 1:50 = 6912
Mean Pow: 5348 ± 2316
Mean log Pow 3.69 ± 0.24
Description of key information
The partition coefficient of the test material was determined in accordance with a method similar to the slow stirring method. Under the conditions of the test, the partition coefficent of the test material was determined to be log Pow 3.69 at 20 °C.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 3.69
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.