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EC number: 687-893-6 | CAS number: 1150560-54-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2nd August 2018 to 31st August 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: MEP The Guidelines for the testing of chemicals No.106. Adsorption - Desorption Using a Batch Equilibrium Method (2013)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 106 (Adsorption - Desorption Using a Batch Equilibrium Method)
- Qualifier:
- according to guideline
- Guideline:
- other: GB/T 21851-2008, Chemicals-Adsorption-desorption using a batch equilibrium method
- GLP compliance:
- yes
- Type of method:
- batch equilibrium method
- Media:
- soil
Test material
- Reference substance name:
- 1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-5-iodo-6-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
- EC Number:
- 687-893-6
- Cas Number:
- 1150560-54-5
- Molecular formula:
- C13H9F4IN2O2
- IUPAC Name:
- 1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-5-iodo-6-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
- Test material form:
- solid: particulate/powder
Constituent 1
Study design
- Test temperature:
- 20 - 25 oC
Batch equilibrium or other method
- Analytical monitoring:
- yes
- Details on sampling:
- Solution Preparation: 0.01 mol/L CaCl2 was prepared by dissolving 1.11 g CaCl2 into 1000 mL ultra water.
1) Test 1 - Preliminary Study
(a) Solution/soil ratio 5:1
5.0g soil with 25 mL solution (0.01 mol/L CaCl2) was agitated at 160rpm for at least 12 hours at 20-25 0C in order to achieve pre-equilibrium. Then 25μL of stock solution of 2000 mg/L was added to the aqueous phase to achieve a nominal concentration of 2mg/L. The another 24 hours agitation was run to reach adsorption equilibrium . Both the concentration of aqueous and oil phases were measured on 2nd, 4th, 6th and 24th hours to calculate the adsorption percentage and mass balance rate.
A blank run per soil with the same amount of soil with 0.01 mol/L CaCl2 solution (without test substance) were subjected to the same test procedure.
(b) Solution/soil ratio 25:1 - black soil and paddy soil
2.0g soil with 50mL solution (0.01 mol/L CaCl2) was agitated at 160rpm for at least 12 hours at 20-25 0C in order to achieve pre-equilibrium. Then 50μL stock solution of 2000 mg/L was added to the aqueous phase to achieve a nominal concentration of 2mg/L. The another 24 hours agitation was run to reach adsorption equilibrium . Both the concentration of aqueous and oil phases were measured on 2nd, 4th and 6th hours to calculate the adsorption percentage and mass balance rate.
2) Tier-2 absorption kinetics and desorption percentage at one single concentration
Solution/soil ratio 5:1 (red, moisture and aquic-brown) and 25:1 (black and paddy)
5.0g soil (red, moisture and aquic-brown) with 25mL solution (0.01 mol/L CaCl2) and 2.0g soil (black and paddy) with 50mL solution (0.01 mol/L CaCl2) were weighed into a 250ml centrifugal tube. After 12 hours equilibrium at 20-25 0C, 25μL (5:1) and 50μL (25:1) of stock solution of 2000 mg/L was added to the aqueous phase to achieve a nominal concentration of 2 g/L. The another 4 hours agitation was run to reach adsorption equilibrium. The volume of supernatant was recorded and an equal volume of 0.01 mol/L CaCl2 substituted for the desorption test. The concentration in the aqueous phase was measured on 2nd, 4th, and 20th hours to calculate desorption.
3) Tier-3 adsorption isotherms and desorption co-efficients
a) Adsorption isotherms
All 5 soils were used. Five test concentrations were run, 0.2, 0.4, 1.0, 2.0 and 5.0mg/L. A series of CaCl2 solution control units with concentrations of 0.2, 0.4, 1.0, 2.0 and 5.0mg/L were run in the same conditions.
b) Desorption co-efficients
The soil and aqueous phases were separated when adsorption equilibrium was reached. The volume of supernatant was recorded and replaced with an equal volume of 0.01mol/L CaCl2 for the desorption test. Another 4 hours agitation was run to achieve equilibrium.
Matrix propertiesopen allclose all
- Matrix no.:
- #1
- Matrix type:
- other: Paddy Soil
- % Clay:
- 18.1
- % Silt:
- 17.1
- % Sand:
- 63.9
- % Org. carbon:
- 1.96
- pH:
- 3.88
- Matrix no.:
- #2
- Matrix type:
- other: Aquic Brown Soil
- % Clay:
- 16.5
- % Silt:
- 42.8
- % Sand:
- 39.9
- % Org. carbon:
- 2.06
- pH:
- 5.47
- Matrix no.:
- #3
- Matrix type:
- other: Red Soil
- % Clay:
- 53.8
- % Silt:
- 28.5
- % Sand:
- 16.8
- % Org. carbon:
- 1.94
- pH:
- 4.93
- Matrix no.:
- #4
- Matrix type:
- other: Black Soil
- % Clay:
- 33.4
- % Silt:
- 25.9
- % Sand:
- 39.3
- % Org. carbon:
- 2
- pH:
- 6.54
- Matrix no.:
- #5
- Matrix type:
- other: Moisture Soil
- % Clay:
- 24.6
- % Silt:
- 24.2
- % Sand:
- 50.9
- % Org. carbon:
- 1.22
- pH:
- 7.87
- Details on matrix:
- COLLECTION AND STORAGE
- Geographic location: Huai'an - Jiangsu Province, Shenyang - Liaoning Province, Qidong - Hanon
Province, Suihua - Heilongjiang Province and Heze - Shendong Province
- Storage conditions: Room Temperature
- Soil preparation: 2 mm sieved
PROPERTIES
- % sand (thin 0.2 - 0.02): 63.9, 39.9, 16.8, 39.3 and 50.9
- % sand (crude 2 - 0.2): 0.9, 0.8, 0.9, 1.4 and 0.3
- % silt: 17.1, 42.8, 28.5, 25.9 and 24.2
- % clay: 18.1, 16.5, 53.8, 33.4 and 24.6
- pH: 6.88, 5.47, 4.93, 6.54 and 7.87
- Organic carbon (%): 1.96, 2.06, 1.94, 2.00 and 1.22
Duration of adsorption equilibrationopen allclose all
- Sample No.:
- #1
- Duration:
- 4 h
- Temp.:
- 20 - 25 °C
- Sample No.:
- #2
- Duration:
- 4 h
- Temp.:
- 20 - 25 °C
- Sample No.:
- #3
- Duration:
- 4 h
- Temp.:
- 20 - 25 °C
- Sample No.:
- #4
- Duration:
- 4 h
- Temp.:
- 20 - 25 °C
- Sample No.:
- #5
- Duration:
- 4 h
- Temp.:
- 20 - 25 °C
Duration of desorption equilibrationopen allclose all
- Sample no.:
- #1
- Duration:
- 4 h
- Temp.:
- 25 °C
- Sample no.:
- #2
- Duration:
- 4 h
- Temp.:
- 25 °C
- Sample no.:
- #3
- Duration:
- 4 h
- Temp.:
- 25 °C
- Sample no.:
- #4
- Duration:
- 4 h
- Temp.:
- 25 °C
- Sample no.:
- #5
- Duration:
- 4 h
- Temp.:
- 25 °C
Results and discussion
Adsorption coefficientopen allclose all
- Key result
- Sample No.:
- #1
- Type:
- log Koc
- Value:
- 3.03
- Matrix:
- Paddy soil
- Key result
- Sample No.:
- #2
- Type:
- log Koc
- Value:
- 2.82
- Matrix:
- Aquic brown soil
- Key result
- Sample No.:
- #3
- Type:
- log Koc
- Value:
- 2.38
- Matrix:
- Red soil
- Key result
- Sample No.:
- #4
- Type:
- log Koc
- Value:
- 3.28
- Matrix:
- Black soil
- Key result
- Sample No.:
- #5
- Type:
- log Koc
- Value:
- 2.56
- Matrix:
- Moisture soil
Results: Batch equilibrium or other method
Mass balance (%) at end of adsorption phaseopen allclose all
- Sample no.:
- #1
- Duration:
- 6 h
- % Adsorption:
- 90.8
- Remarks on result:
- other: Solution/soil ratio 25:1
- Sample no.:
- #4
- Duration:
- 6 h
- % Adsorption:
- 95.4
- Remarks on result:
- other: Solution/soil ratio 25:1
- Sample no.:
- #1
- Duration:
- 24 h
- % Adsorption:
- 100.7
- Remarks on result:
- other: Solution/soil ratio 5:1
- Sample no.:
- #2
- Duration:
- 24 h
- % Adsorption:
- 91.7
- Remarks on result:
- other: Solution/soil ratio 5:1
- Sample no.:
- #3
- Duration:
- 24 h
- % Adsorption:
- 90.2
- Remarks on result:
- other: Solution/soil ratio 5:1
- Sample no.:
- #4
- Duration:
- 24 h
- % Adsorption:
- 101.9
- Remarks on result:
- other: Solution/soil ratio 5:1
- Sample no.:
- #5
- Duration:
- 24 h
- % Adsorption:
- 88.3
- Remarks on result:
- other: Solution/soil ratio 5:1
- Sample no.:
- #1
- Duration:
- 4 h
- % Adsorption:
- 100.5
- Remarks on result:
- other: Solution/soil ratio 5:1
- Sample no.:
- #2
- Duration:
- 4 h
- % Adsorption:
- 99.1
- Remarks on result:
- other: Solution/soil ratio 5:1
- Sample no.:
- #3
- Duration:
- 4 h
- % Adsorption:
- 90.4
- Remarks on result:
- other: Solution/soil ratio 5:1
- Sample no.:
- #4
- Duration:
- 4 h
- % Adsorption:
- 106.3
- Remarks on result:
- other: Solution/soil ratio 5:1
- Sample no.:
- #5
- Duration:
- 4 h
- % Adsorption:
- 90.2
- Remarks on result:
- other: Solution/soil ratio 5:1
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Methyl Iodouracil has a moderate adsorption potential and the adsorption was deduced to be irreversible.
- Executive summary:
The HPLC was employed to determine the test item Methyl Iodouracil. The recovery test in 0.01 mol/L Ca Cl2 was set up at two concentrations, 0.1 and 5 mg/L. The mean recovery rate was in the range of 83.1 - 86% with RSD in the range 1.2 - 7.1%. The recovery test in soils was based on three concentrations 0.5, 1.0 and 50mg/kg. The mean recovery rate was in the range of 85.8 - 105.2% with RSD in the range 0.1 - 7.2%. The analytical method met the quality criteria.
A batch equilibrium method was performed on the basis of MEP Guidelines for the Testing of Chemicals (2013) No. 106 Adsorption/desorption using a Batch Equilibrium Method.
The red soil, moisture soil, aquic-brown soil, black soil and paddy soil were employed in the adsorption isotherm test, 5:1 was employed for the three former soils and 25:1 for the latter two. The equilibrium time was four hours.
The concentrations were 0.2, 0.4, 1,2 and 5 mg/L. The log Koc of red soil, moisture soil, aquic-brown soil, black soil and paddy soil were 2.38, 3.03, 3.28, 2.56 and 2.82 mg/L respectively. With a desorption equilibrium time selection of 4 hours, the mean Kdes of red soil, moisture soil, aquic-brown soil, black soil and paddy soil were 179.9, 75.9, 76.2, 27.9 and 24.4 respectively.
The test iterm has a moderate adsorption potential and the adsorption was deduced to be irreversible.
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