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EC number: 701-234-2 | CAS number: 18402-84-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009-04-16 to 2009-07-24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2400 (Acute Eye Irritation)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- (3E)-dec-3-en-2-one
- Cas Number:
- 18402-84-1
- Molecular formula:
- C10H18O
- IUPAC Name:
- (3E)-dec-3-en-2-one
- Details on test material:
- - CAS: 18402-84-1
- Purity: 98.57% to 99.11% w/w
- Batch No.: Lot KB 147-36-1
- Physical state: liquid
- Colour: Colorless to pale yellow
- Storage conditions: room temperature
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: New Zealand albino
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Received from Robinson Services, Inc. Clemmons, NC on April 29 and May 20, 2009.
- Age at study initiation: Young adult.
- Housing: The animals were singly housed in suspended stainless steel caging with mesh floors which conform to the size recommendations in the most recent Guide for the Care and Use of Laboratory Animals DHEW (NIH). Litter paper was placed beneath the cage and was changed at least three times per week.
- Diet: Pelleted Purina Rabbit Chow #5326
- Water: Filtered tap water was supplied ad libitum by an automatic water dispensing system.
- Acclimation period: 12 or 19 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-22
- Humidity (%): 36-70
- Photoperiod (hrs dark / hrs light): 12-hour light/dark cycle
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye used as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL - Duration of treatment / exposure:
- 0.1 mL of the test substance was instilled into the conjunctival sac of the right eye of the first rabbit by pulling the lower lid away from the eyeball. The upper and lower lids were then gently held together for about one second before releasing to minimize loss of the test substance.
- Observation period (in vivo):
- 1, 24, 48 and 72 hours and day 4, 7 and 10 after instillation
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no
- Time after start of exposure: not applicable
SCORING SYSTEM: according to Draize
TOOL USED TO ASSESS SCORE: Ocular irritation was evaluated using a high-intensity white light (Mag Lite) in accordance with Draize et al.. The fluorescein dye evaluation was used in the treated eye at 24 hours to verify the absence of corneal damage.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 3
- Reversibility:
- fully reversible within:
- Remarks:
- 10 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1.66
- Max. score:
- 3
- Reversibility:
- fully reversible within:
- Remarks:
- 4 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 3
- Reversibility:
- fully reversible within:
- Remarks:
- 4 days
- Irritant / corrosive response data:
- One hour after test substance instillation, all three treated eyes exhibited corneal opacity and 'positive' conjunctivitis and two treated eyes exhibited iritis. The overall incide\}ce and severity of irritation decreased gradually with time. All animals were free of ocular irritation by Day 10. For detailed results please refer to table 1 in box "Any other information on results incl. tables".
- Other effects:
- All animals appeared active and healthy during the study. Apart from the eye irritation noted in Table 1 below there were no other signs of gross toxicity, adverse pharmacologic effects, or abnormal behavior.
Any other information on results incl. tables
Table 1 : Eye irritation score
Animal No |
Effect |
Time after administration |
||||||
Hours |
Days |
|||||||
1 |
24 |
48 |
72 |
4 |
7 |
10 |
||
3401 |
Redness |
2 |
2 |
1 |
1 |
1 |
1 |
0 |
Chemosis |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
|
Discharge |
2 |
1 |
1 |
1 |
1 |
1 |
0 |
|
Iritis |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
Opacity |
1 |
1* |
0 |
0 |
0 |
0 |
0 |
|
Area |
2 |
1 |
4 |
4 |
4 |
4 |
4 |
|
3402 |
Redness |
2 |
2 |
2 |
1 |
0 |
0 |
- |
Chemosis |
2 |
0 |
0 |
0 |
0 |
0 |
- |
|
Discharge |
3 |
2 |
2 |
1 |
0 |
0 |
- |
|
Iritis |
1 |
0 |
0 |
0 |
0 |
0 |
- |
|
Opacity |
1 |
0* |
0 |
0 |
0 |
0 |
- |
|
Area |
2 |
4 |
4 |
4 |
4 |
4 |
- |
|
3403 |
Redness |
2 |
2 |
1 |
1 |
0 |
0 |
- |
Chemosis |
2 |
0 |
0 |
0 |
0 |
0 |
- |
|
Discharge |
3 |
2 |
2 |
1 |
1 |
0 |
- |
|
Iritis |
1 |
0 |
0 |
0 |
0 |
0 |
- |
|
Opacity |
1 |
0* |
0 |
0 |
0 |
0 |
- |
|
Area |
1 |
4 |
4 |
4 |
4 |
4 |
- |
* 2% ophthalmic fluorescein sodium used to verify the absence of corneal opacity.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- (3E)-dec-3-en-2-one caused irritation when applied to rabbit eyes, but does not warrant classification as an eye irritant in accordance to CLP regulation 1272/2008.
- Executive summary:
In a primary eye irritation study conducted in accordance to OECD guideline 404, 0.1 mL of the test item was instilled into the conjunctival sac of the right eye of three young adult female New Zealand albino rabbits. Animals then were observed for 10 days. Irritation was scored by the method of Draize. All animals appeared active and healthy during the study. There were no other signs of gross toxicity, adverse pharmacologic effects, or abnormal behaviour. One hour after test substance instillation, all three treated eyes exhibited corneal opacity and 'positive' conjunctivitis and two treated eyes exhibited iritis. The overall incidence and severity of irritation decreased gradually with time. All animals were free of ocular irritation by Day 10. Based on the results, no classification for eye irritation is warranted in accordance to CLP regulation 1272/2008.
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