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EC number: 291-716-4 | CAS number: 90459-71-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From July 02 to July 15, 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.1010 (Aquatic Invertebrate Acute Toxicity Test, Freshwater Daphnids)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Octadecanoic acid, reaction products with triethylenetetramine, chloromethane-quaternized
- EC Number:
- 291-716-4
- EC Name:
- Octadecanoic acid, reaction products with triethylenetetramine, chloromethane-quaternized
- Cas Number:
- 90459-71-5
- Molecular formula:
- Not applicable - UVCB substance
- IUPAC Name:
- Octadecanoic acid, reaction products with triethylenetetramine, chloromethane-quaternized
- Test material form:
- solid
1
- Specific details on test material used for the study:
- Test item name : Octadecanoic acid, reaction products with triethylenetetramine, chloromethane-quaternized
Batch number : I1-0000196125
Internal number : 1901277-001
Manufacturing date : July 28, 2018
Expiry date : July 28, 2019
C.A.S. number : 90459-71-5
EEC number : 291-716-4
Molecular weight : UVCB substance
Empirical formula : UVCB substance
Storage : room temperature
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- yes
- Remarks:
- reconstituted water
- Details on test solutions:
- The test medium was prepared as follows:
prior to the test start, a 10.0 mg test item/L stock solution was prepared by direct weighting of 0.0050 g of test item into 500 mL of reconstituted water. The obtained solution appeared clear with particles if test item. This solution was sonicated for about five minutes and after was stirring with magnetic stirrer for about 2 hours. After stirring the stock solution appeared clear and transparent.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- A strain of Daphnia magna Straus was supplied by MicroBioTests Inc., Belgium in July 2017 (batch number: DM060417).
Since that time, the clone has been bred in the laboratories of the Test Facility under conditions identical to those of the test, with regard to temperature, light and water quality, so that no acclimation was needed prior to testing.
It was daily fed with a fixed amount of the laboratory cultured green algae Pseudokirchneriella subcapitata (formerly Selenastrum capricornutum) and with a suspension of the yeast Saccharomyces cerevisiae.
At the test start the organisms used in the test were less than 24 hours old and were not first brood progeny.
For the test concentration and for the negative control, group of 20 daphnids were used divided into four replicates of five daphnids each. The daphnids were randomly distributed to the test vessels at test initiation. The daphnids loading rate was about 8 mL per one daphnid
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 140 - 250 mg/L as CaCO3
- Test temperature:
- 19.9 – 20.1 °C.
- pH:
- negative control: 7.04 – 7.12
test item solution: 7.18 – 7.89 - Dissolved oxygen:
- negative control: 6.36 – 7.82 mg O2/L
test item solution: 6.13 – 7.39 mg O2/L - Nominal and measured concentrations:
- Negative control (reconstituted water without test item) and 0.4, 0.9, 2.1, 4.6 and 10.0 mg test item/L.
- Details on test conditions:
- Light intensity: 1222 - 1293Lux.
Light Regime: 16 hours light and 8 hours dark. - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate solution
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 2.2 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.9 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.4 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mobility
Any other information on results incl. tables
The observed immobilization in the negative control and test item concentration is reported in following Table.
Nominal test item concentration (mg/L) |
No. of |
No. of immobilized |
% of immobilized |
||
24 h |
48 h |
24 h |
48 h |
||
0.0 (negative control) |
20 |
0 |
0 |
0 |
0 |
0.4 |
20 |
0 |
0 |
0 |
0 |
0.9 |
20 |
0 |
11 |
0 |
55 |
2.1 |
20 |
8 |
18 |
40 |
90 |
4.6 |
20 |
20 |
20 |
100 |
100 |
10.0 |
20 |
20 |
20 |
100 |
100 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- A full test at five concentrations, 0.4, 0.9, 2.1, 4.6 and 10.0 mg test item/L, was performed to evaluate the effect of the test item on Daphnia magna under static conditions.
The daphnids were observed for immobility after 24 and 48 hours of exposure.
EC0, EC100, EC50 (with their confidential limit) and NOEC, expressed in terms of nominal test item concentration, were as follows:
Time (h) EC0 (mg/L) EC100 (mg/L) EC50 (mg/L) NOEC (mg/L)
24 0.9 4.6 2.2 (1.9 – 2.7) 0.9
48 0.4 4.6 1.0 (0.8 – 1.2) 0.4
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