Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 251-073-2 | CAS number: 32509-66-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
no study available
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
There are no studies available in which the toxicokinetic properties of Ethylene-bis[3,3-bis(3-tert.-butyl-4-hydroxyphenyl)butyrate]were investigated.
Ethylene-bis[3,3-bis(3-tert.-butyl-4-hydroxyphenyl)butyrate](molecular weight: 795 g/mol) is a white crystalline solid, which is considered to be hydrolytically stable. Its water solubility is determined to be 0.5 mg/L at 20°C (see chapter 4.8). The octanol water partition coefficient (Log Pow) value of > 6.5 was obtained for Ethylene bis[3,3-bis(3-tert-butyl-4-hydroxyphenyl)butyrate], using a HPLC method. (see chapter 4.7). Due to the relative high Log Powof 13.66 in combination with only a slight hydrolysis of the substance (see chapter 5.1.2) a general low potential of bioaccumulation might be considered.
Absorption
With reference to the Log Powof 13.66, the very limited water solubility and the molecular weight of 795 g/mol the absorption of Ethylene-bis[3,3-bis(3-tert.-butyl-4-hydroxyphenyl)butyrate] is considered to be very poor (please refer to Guidance on information requirements and chemical assessment, Chapter R.7c, Table R.7.12-1, p. 152). Furthermore, the substance contains several hydroxyl functions which might be ionisable. Ionisation does not contribute to a readily diffusion across biological membranes (please refer to Guidance on information requirements and chemical assessment, Chapter R.7c, p. 150). Therefore, a large-scale absorption of Ethylene-bis[3,3-bis(3-tert.-butyl-4-hydroxyphenyl)butyrate] might be excluded. This assumption is strengthened by the results of the acute oral toxicity studies in rats (LD50> 15,000 mg/kg bw). However, since some (unspecific) effects were observed in the course of repeated dose studies at high doses a small amount of the substance is proved to be bioavailable. The absorption of highly lipophilic substances might be by micellar solubilisation by bile salts and subsequent entering the circulation via the lymphatic system (please refer to Guidance on information requirements and chemical assessment, Chapter R.7c, p. 150).
Distribution
Ethylene-bis[3,3-bis(3-tert.-butyl-4-hydroxyphenyl)butyrate]is a very lipophilic substance with a high molecular weight. Therefore, it will tend to migrate into cells and concentrate in adipose tissues (please refer to Guidance on information requirements and chemical assessment, Chapter R.7c, pp. 159-160). The accumulation in milk also can not be excluded. This possible distribution pattern might explain the observations made in pups in the course of the reproductive toxicity studies while the lactation phase.
Metabolism
Taking into accountthe Log Powof 13.66, the very limited water solubility and the molecular weight of 795 g/mol, an uptake of considerable amounts of this substance is very unlikely to occur. However, absorption of small amounts can not be excluded.
Studies on genotoxicity performed with theof Ethylene-bis[3,3-bis(3-tert.-butyl-4-hydroxyphenyl)butyrate](Ames-Test; chromosome aberration test and HPRT test) were negative, i.e. there is no indication of a reactivity of the substance under the test conditions. The assumption of a very limited metabolism ofof Ethylene-bis[3,3-bis(3-tert.-butyl-4-hydroxyphenyl)butyrate] is supported by the proven low tendency to hydrolyze and the poor water solubility. However, a cleavage of the ester functions in the molecular center is thinkable.
Excretion
With reference to the high Log Powand molecular weight the biliary excretion might be the considered as the most favorable excretion route. Therefore, enterohepatic recycling resulting in a prolonged biological half-life can not be excluded (please refer to Guidance on information requirements and chemical assessment, Chapter R.7c, p. 161).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.