Registration Dossier
Registration Dossier
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EC number: 232-167-2 | CAS number: 7789-45-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- EU RISK ASSESSMENT - [COPPER, COPPER II SULPHATE PENTAHYDRATE, COPPER(I)OXIDE, COPPER(II)OXIDE, DICOPPER CHLORIDE TRIHYDROXIDE] CAS [7440-50-8, 7758-99-8, 1317-39-1, 1317–38–0, 1332-65-6] CHAPTER 4.1.2. HUMAN HEALTH - EFFECTS ASSESSMENT
- Author:
- RAPPORTEUR: ITALY
- Year:
- 2 007
- Bibliographic source:
- European Copper Institute
Materials and methods
Test material
- Reference substance name:
- Copper
- EC Number:
- 231-159-6
- EC Name:
- Copper
- Cas Number:
- 7440-50-8
- Molecular formula:
- Cu
- IUPAC Name:
- copper
1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- The most reliable and relevant dose-response data for acute toxicity come from two well-controlled, oral exposure studies conducted in human volunteers (Araya et al, 2001; Araya et al, 2003). In both of these studies, a concentration-related increase in gastrointestinal symptoms was associated with single oral exposure to copper in drinking water. The NOAEL for gastrointestinal symptoms in adults was 4 mg Cu/litre drinking water (0.8 mg Cu) and the LOAEL was 6 mg/litre (1.2 mg Cu).
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