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Diss Factsheets
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EC number: 608-174-5 | CAS number: 28183-82-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Screening test 2018. Assessed over 5 days
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Justification for type of information:
- Due to the nature of the UVCB substance, it was impossible to determine the precise identity of specific components and their transformation products. Instead, differences in composition resulting from dilution in water over 5 days was used to indicate that some changes were happening at a range of pH conditions.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Version / remarks:
- Screening test; as it was impossible to identify specific components of the UVCB and their transformation products, a full study was not possible to perform.
- Principles of method if other than guideline:
- LCMS used to look for different peak characteristics after 5 days diluted in water buffered to pH 4, 7 and 9
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Batch PAH225/139/5
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- Samples for analysis at time of preparation and after 5 days in water
- Buffers:
- pH 4 - acetic acid / sodium acetate
pH 7 - sodium hydroxide / potassium phosphate
pH 9 - sodium hydroxide / boric acid - Details on test conditions:
- A volume of 100 ml was held for 5 days at 53 C
- Duration:
- 5 d
- pH:
- 4.55
- Temp.:
- 53 °C
- Initial conc. measured:
- > 1.148 - < 1.47 g/L
- Duration:
- 5 d
- pH:
- 7.35
- Temp.:
- 53 °C
- Initial conc. measured:
- > 1.279 - < 1.286 g/L
- Duration:
- 5 d
- pH:
- 9.2
- Temp.:
- 53 °C
- Initial conc. measured:
- > 1.322 - < 1.388 g/L
- Number of replicates:
- Two replicates per pH.
- Positive controls:
- no
- Negative controls:
- no
- Preliminary study:
- Preliminary study identified changes in peak elution times and intensity, but specific components of the UVCB not possible to identify by these methods.
- Transformation products:
- not measured
- Remarks:
- Not possible to identify
- Details on hydrolysis and appearance of transformation product(s):
- The samples fully dissolved in the buffers. No changes in appearance were reported.
- Key result
- pH:
- 4
- Temp.:
- 53 °C
- Remarks on result:
- not determinable because of methodological limitations
- Remarks:
- Specific transformation products were not possible to identify
- Key result
- pH:
- 7
- Temp.:
- 53 °C
- Remarks on result:
- not determinable because of methodological limitations
- Remarks:
- Specific transformation products were not possible to identify
- Key result
- pH:
- 9
- Temp.:
- 53 °C
- Remarks on result:
- not determinable because of methodological limitations
- Remarks:
- Specific transformation products were not possible to identify
- Other kinetic parameters:
- These were not possible to determine
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The authors of the report were unable to identify any specific components and transformation products, but MS investigations following LC separation indicated that higher molecular weight components (identified as 'polymer' in the report) were significantly reduced suggesting mechanisms such as cleavage.
It is however possible that the substance interacted with buffers, forming salts. The substance is manufactured and supplied in water and manufacture includes some hydrolysis steps with evolution of ammonia. Further hydrolysis is therefore unlikely under the conditions of pH 4, 7 and 9 and it should also be noted that the substance is used in dilute aqueous mixtures for water treatment.
Reference
Due to changes in the elution times, intensity and 'appearance' of peaks at a detection wave length of 230 nm, changes in the test material were observed over 5 days at pH 4, 7 and 9 when held at 53 C. Note that the pH ncreased under all test conditions from initial buffered pH.
The authors of the report were unable to identify any specific components and transformation products, but MS investigations following LC separation indicated that higher molecular weight components (identifed as 'polymer' in the report) were significantly reduced suggesting mechanisms such as cleavage.
Description of key information
The authors of the report were unable to identify any specific components and transformation products, but MS investigations following LC separation indicated that higher molecular weight components (identifed as 'polymer' in the report) were significantly reduced suggesting mechanisms such as cleavage.
It is however possible that the substance interacted with buffers, forming salts. The substance is manufactured and supplied in water and manufacture includes some hydrolysis steps with evolution of ammonia. Further hydrolysis is therefore unlikely under the conditions of pH 4, 7 and 9 and it should also be noted that the substance is used in dilute aqueous mixtures for water treatment.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.