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EC number: 273-105-4 | CAS number: 68937-98-4 This substance is identified by SDA Substance Name: C14-C18 and C12-C20 unsaturated alkyl alkene and C14-C18 and C12-C20 unsaturated alkyl hydroxy sulfonic acid sodium salt and SDA Reporting Number: 03-059-04.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 January 2018 - 22 March 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Remarks:
- HPLC-MS/MS
- Details on sampling:
- - Nominal Concentrations: 1.0, 1.8, 3.2, 5.6 and 10 mg/L.
- Geometric Mean Measured Test Concentration (mg/L): 0.61, 1.6, 2.8, 5.7 and 9.7
- Sample storage conditions before analysis: All samples were stored frozen prior to analysis - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
-A nominal amount of test item (50 mg) was dissolved in test water and the volume adjusted to 500 mL to give the 100 mg/L test concentration from which a series of dilutions was made to give further test concentrations of 0.10, 1.0 and 10 mg/L.
Based on the results of the range-finding test the following test concentrations were assigned to the definitive test: 1.0, 1.8, 3.2, 5.6 and 10 mg/L.
A nominal amount of test item (20 mg) was dissolved in test water and the volume adjusted to 2 liters to give the 10 mg/L test concentration from which a series of dilutions was made to give further test concentrations of 1.0, 1.8, 3.2 and 5.6 mg/L. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Source: in-house laboratory cultures
- Feeding during test: none
ACCLIMATION
- Type and amount of food:mixture of algal suspension (Desmodesmus subspicatus) and Tetramin® flake food suspension.
- Feeding frequency: daily - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- not specified
- Test temperature:
- 18 to 22 °C with a maximum deviation of ±1 °C
- pH:
- 7.7 - 8.2
- Dissolved oxygen:
- 8.2 - 9.2 mg /L
- Salinity:
- not specified
- Conductivity:
- not specified
- Nominal and measured concentrations:
- - Nominal Concentrations: 1.0, 1.8, 3.2, 5.6 and 10 mg/L.
- Geometric Mean Measured Test Concentration (mg/L): 0.61, 1.6, 2.8, 5.7 and 9.7 - Details on test conditions:
- TEST SYSTEM
- Type: closed
- No. of organisms per vessel: 5
- replicates: 4
OTHER TEST CONDITIONS
- Photoperiod: 16 hours light and 8 hours darkness cycle with 20 minute dawn and dusk transition periods.
- Light intensity: between 200 and 1200 Lux
RANGE-FINDING STUDY
- Test concentrations: 0.10, 1.0, 10 and 100 mg/L.
- Results used to determine the conditions for the definitive study: yes - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- ca. 0.61 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- ca. 1.6 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 1.1 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Abnormal responses: A single daphnia was observed to have reduced movement in the control group at 24 hours however, this was considered not to have had an impact on the outcome of the test given that no more than 10% were affected.
- Results with reference substance (positive control):
- - Results with reference substance valid?
yes
- EC50 : 24hours 0.79mg/L and 48 hours 0.75mg/L,
- NOEC: 24 hours 0.56 mg/L and 48 hours 0.56 mg/L
- LOEC: 24 hours 1.0 mg/L and 48 hours 1.0 mg/L
- Other: potassium dichromate as the reference item at concentrations of 0.32, 0.56, 1.0, 1.8 and 3.2 mg/L - Reported statistics and error estimates:
- not specified
- Validity criteria fulfilled:
- yes
- Remarks:
- The test was considered to be valid given that no more than 10% of the control daphnids showed immobilization or other signs of disease or stress
- Conclusions:
- 48 hours: EC50 = 1.1 mg/L, NOEC = 0.61 mg/L, LOEC = 1.6 mg/L
Reference
Description of key information
Daphna Magma, 48 hours:
EC50 = 1.1 mg/L,
NOEC = 0.61 mg/L,
LOEC = 1.6 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 1.1 mg/L
Additional information
A determination of the acute toxicity to aquatic invertebrates Sulfonic acids, C14-18-alkane hydroxy and C12-20-alkapolyene and C14-18-alkene and C12-20-alkene hydroxy, sodium salts was conducted under semi-static test conditions (Envigo Research Limited, 2018). The study was performed in accordance with EC method C2 and OECD test guideline 202, and in compliance with GLP. Groups of 20 Daphnia magna were exposed to 0 (control group), 0, 0.61, 1.6, 2.8, 5.7 and 9.7 mg/L (geometric mean measured concentration) Sulfonic acids, C14-18-alkane hydroxy and C12-20-alkapolyene and C14-18-alkene and C12-20-alkene hydroxy, sodium salts in Elendt M7 Culture medium.
After 48 hours, 95% of the Daphnia in the 1.6, and all 2.8, 5.7 and 9.7 mg/L concentration groups were immobilised. This response was reduced mobility and covered with debris. None of the Daphnia in the lower concentration group were immobilised. A single daphnia was observed to have reduced movement in the control group at 24 hours however, this was considered not to have had an impact on the outcome of the test given that no more than 10% were affected
It was concluded that the 48 hour EC50 in Daphnia Magna was 1.1 mg/L. The no-observed effect concentration was concluded to be 0.61 mg/L.
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