Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 481-830-4 | CAS number: 3687-22-7
Toxicity to reproduction
Administrative data
- Endpoint:
- two-generation reproductive toxicity
- Remarks:
- based on test type (migrated information)
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: read across
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- read across
- GLP compliance:
- no
Test material
- Details on test material:
- reead across
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Brown Norway
- Sex:
- male/female
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
- Dose descriptor:
- LOEL
- Effect level:
- 665 mg/kg bw/day (nominal)
- Sex:
- male/female
- Basis for effect level:
- other: read across report
- Remarks on result:
- other: Generation not specified (migrated information)
Results: F1 generation
Effect levels (F1)
- Remarks on result:
- not determinable
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
Kidney Pathology and Weight ; Second generation adult parental animals or first generation juvenile (young) offspring from P1 adult animals (specific to effect)( F1)
Liver Pathology and Weight ; First generation adult parental animals( P1)
Liver Pathology and Weight ; Second generation adult parental animals or first generation juvenile (young) offspring from P1 adult animals (specific to effect)( F1)
Kidney Pathology and Weight ; First generation adult parental animals( P1)
Decrease in Implantations ; First generation adult parental animals( P1)
Decrease in Implantations ; Second generation adult parental animals or first generation juvenile (young) offspring from P1 adult animals (specific to effect)( F1)
Decreased Litter Size ; Second generation adult parental animals or first generation juvenile (young) offspring from P1 adult animals (specific to effect)( F1)
Ovary Pathology and Weight ; First generation adult parental animals( P1)
Ovary Pathology and Weight ; Second generation adult parental animals or first generation juvenile (young) offspring from P1 adult animals (specific to effect)( F1)
Kidney Pathology and Weight ; First generation adult parental animals( P1)
Kidney Pathology and Weight ; Second generation adult parental animals or first generation juvenile (young) offspring from P1 adult animals (specific to effect)( F1)
Liver Pathology and Weight ; First generation adult parental animals( P1)
Liver Pathology and Weight ; Second generation adult parental animals or first generation juvenile (young) offspring from P1 adult animals (specific to effect)( F1)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
