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Diss Factsheets
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EC number: 400-640-4 | CAS number: 198153-89-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21 - 25 Nov 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- May 1981
- GLP compliance:
- not specified
- Analytical monitoring:
- yes
- Details on sampling:
- Water samples were taken from the bath at the beginning and at the end of the experiment
- Vehicle:
- no
- Details on test solutions:
- Direct weighing of 3 g substance in 3 L diluent (reconstituted water according to ISO 7346), stirring until complete dilution
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: zebrafish
- Source: West-Aquarium, Bad Lauterberg, Germany
- Age at study initiation: 4.5 months
- Length at study initiation (mean): 2.8 cm
- Weight at study initiation (mean): 0.27 g
ACCLIMATION
- Acclimation period: 46 d in dechlorinated tap water
- Acclimation conditions (same as test or not): same except medium
FEEDING DURING TEST
None - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 100 mg/L (CaCO3)
- Test temperature:
- 23.0 - 24.5°C
- pH:
- 7.5 - 7.8
- Dissolved oxygen:
- 7.4 - 8.2 mg/L
- Nominal and measured concentrations:
- 0 (control), 1000 mg/L nominal
0 (control), 1030 (initial) - 1056 (end) mg/L measured corresponding to 103 - 106% of nominal concentration - Details on test conditions:
- TEST SYSTEM
- Test vessel: aquaria
- Material, size, headspace, fill volume: glass, 5 L (3 L fill volume)
- Aeration: slowly
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- Biomass loading rate: 1 animal / 300 mL
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: tap water
- Culture medium different from test medium: yes, dechlorinated tap water vs. reconstituted water (ISO 7346)
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 12/12 h
- Light intensity: yellow light TL16 / 20W
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : mortality at 3, 24, 48, 72 and 96h after start of exposure
TEST CONCENTRATIONS
- 1000 mg/L limit test
- Range finding study
- Test concentrations: 100, 300 and 1000 mg/L
- Results used to determine the conditions for the definitive study: yes, no mortality occurred in pre-test - Reference substance (positive control):
- no
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: analytically verified
- Details on results:
- 0% mortality in test concentration and negative control
LC0 > 1000 mg/L - Results with reference substance (positive control):
- N/A
- Reported statistics and error estimates:
- None
- Validity criteria fulfilled:
- yes
- Conclusions:
- The substance has a 96-h LC50 > 1000 mg/L to fish (analytically verified). Reactive Yellow 161 did not cause any lethal effects up to 1000 mg/L in an OECD 203 study with Danio rerio.
Reference
Description of key information
The substance has a 96-h LC50 > 1000 mg/L to fish (analytically verified). Reactive Yellow 161 did not cause any lethal effects up to 1000 mg/L in an OECD 203 study with Danio rerio.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1 000 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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