Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 232-465-2 | CAS number: 8047-99-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: screening test, other
- Remarks:
- Inherent test: shake flask carbon dioxide evolution test ASTM E35.24 (2/80)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Remarks:
- study performed according to guideline and reviewed for compliance with GLP, however relevant and detailed information is lacking in the report, but a reference of where the info can be retrieved is given.
- Qualifier:
- according to guideline
- Guideline:
- other: American Society for Testing Materials, Proposed Standard Practice for the Determination of the Ultimate Biodegradability of Organic Chemicals, Draft No. 3, ASTM E35.24 Subcommittee, Aquatic Biotransformati on Task Group, 2/80
- Version / remarks:
- Identical to that described in ASTM Draft No.3 for the Proposed Standard Practice for the Determination of the Ultimate Biodegradability of Organic Chemicals
- GLP compliance:
- yes
- Remarks:
- page 5 of the report indicates review for compliance with GLP
- Specific details on test material used for the study:
- Santicizer 8 (log #1916320), mixture of N-ethyl-o-toluene sulfonamide and N-ethyl -p-toluene sulfonamide, H3C-C6H4-S02NHC2H5, QH-18 , %C = 54.55
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- mixture of sewage, soil and natural water
- Remarks:
- mixture of soil, raw sewage and activated sludge mixed liquor.
- Details on inoculum:
- mixture of soil, raw sewage and activated sludge mixed liquor
- Duration of test (contact time):
- 35 d
- Initial conc.:
- 25.4 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- an acclimated inoculum is prepared by the stepwise addition of test compound to a defined medium over a 14-day period. This medium is derived·from soil , raw sewage, and activated sludge mixed l i quor. At the conclusi on of the acclimati on period, 100 ml of inoculum are mixed with 900 ml of minimal salts media in a fluted 2-liter Erl enmeyer flask. After aerati ng the mi xture with 70% oxygen in ni trogen, a known quantity of the test compound is added to each flask. An open reservoi r contai ning 10 ml of 0.15N bari um hydroxi de is suspended via a glass tube inserted in a neoprene stopper . Provisions for removal and addition of the bari um hydroxide and for sampling the aqueous media are provided. After sealing, the flasks are agitated on a rotary shaker in the dark at ambient temperature. Periodic removal , e.g., (3, 7, 1 4, 21 , 28, and 35 days) and titration of the barium hydroxide solution are used to determine the C02 evolved. Fresh bari um hydroxide is added back at each sampling point. C02 evol ution values obtained with the control are subtracted from values for the test compound.
Quadruplicate flasks for controls and each plasticizer product were employed. A positive control, sodium citrate, in triplicate flasks was used to monitor biological activity. - Reference substance:
- other: sodium citrate
- Test performance:
- The carbon dioxide evolution for the positive control fell in the expected 70-95 percent range.
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 3
- St. dev.:
- 3
- Sampling time:
- 35 d
- Results with reference substance:
- The carbon dioxide evolution for the positive control fell in the expected 70-95 percent range.
- Validity criteria fulfilled:
- not specified
- Remarks:
- the positive control result was valid
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- Santicizer 8 is slowly biodegraded.
- Executive summary:
Ultimate biodegradation screening using the shake flask carbon dioxide evolution test (according to ASTM E35.24, GLP) was carried out for two specialty plasticizer products, Santicizer 8 and Santicizer 9. 14d Acclimated inoculum was exposed to 25 mg/L test substance for 35 days. The degree of conversion to carbon dioxide for both products was not significant ranging from 3 to 13 percent of theory, indicating relatively slow biodegradation or slight alteration of the parent molecules. Results of the refernce substance was in the expected range, indicating proper test procedures.
Reference
Description of key information
Ultimate biodegradation screening using the shake flask carbon dioxide evolution test (according to ASTM E35.24, GLP) was carried out for two specialty plasticizer products, Santicizer 8 and Santicizer 9. 14d Acclimated inoculum was exposed to 25 mg/L test substance for 35 days. The degree of conversion to carbon dioxide for both products was not significant ranging from 3 to 13 percent of theory, indicating relatively slow biodegradation or slight alteration of the parent molecules. Results of the refernce substance was in the expected range, indicating proper test procedures.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
- Type of water:
- freshwater
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.