Registration Dossier
Registration Dossier
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EC number: 238-242-6 | CAS number: 14306-25-3
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Teratological studies of phytic acid in ICR mice
- Author:
- Ogata A et al
- Year:
- 1 987
- Bibliographic source:
- TOKYO TORITSU EISEI KENKYUSHO NEMPO (38):377-381,1987
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Fytic acid
- EC Number:
- 201-506-6
- EC Name:
- Fytic acid
- Cas Number:
- 83-86-3
- Molecular formula:
- C6H18O24P6
- IUPAC Name:
- cyclohexane-1,2,3,4,5,6-hexayl hexakis[dihydrogen (phosphate)]
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- mouse
Administration / exposure
- Route of administration:
- oral: gavage
Results and discussion
Results: maternal animals
General toxicity (maternal animals)
- Body weight and weight changes:
- effects observed, treatment-related
Results (fetuses)
- Reduction in number of live offspring:
- effects observed, treatment-related
- Description (incidence and severity):
- Fetal loss was observed.
Applicant's summary and conclusion
- Conclusions:
- Based on the study results, the oral administration of phytic acid to mouse by oral route (gavage) may cause maternal weight changes and fetal loss. However, the relibility of the study cannot be assessed due to inconplete information. Overall, data are deemed to be inconclusive to classify.
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