Iodo(triphenylphosphino)copper

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2003

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2003

Report date:

2003

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: OECD 423

GLP compliance:

yes

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Iodo-tris(triphenylphosphine)copper(I)

EC Number:

454-330-9

EC Name:

Iodo-tris(triphenylphosphine)copper(I)

Cas Number:

15709-82-7

Molecular formula:

Hill formula: C54H45CuIP3 CAS formula: C54H45CuIP3

IUPAC Name:

Iodo-tris(triphenylphosphine)copper(I)

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 219001
- Expiration date of the lot/batch: January 01 , 2004

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: dry, room temperature, closed container

Test animals

Species:

rat

Strain:

Wistar

Sex:

female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Charles River Wiga GmbH, D-97320 Sulzfeld
- Females (if applicable) nulliparous and non-pregnant: yes
- Age at study initiation: approximately 6 weeks
- Weight at study initiation: 214.3 g ± 6.8 g (3 .2 %)
- Fasting period before study: yes
- Housing: Makrolon® Type 3 cage
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 6 days before randomisation

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21,0 - 21,5
- Humidity (%): 30 - 40
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: 0.5 % tylose MH 1000 in deionized water

Doses:

2.000 mg/kg

No. of animals per sex per dose:

6

Control animals:

no

Details on study design:

All animals were examined for mortality, clinical signs and body weight gain. The pathological
alterations of organs were examined at the end of a 14-day observation period.

Results and discussion

Effect levels

Sex:

female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

Female: 2000 mg/kg bw; Number of animals: 6; Number of deaths: 0

Clinical signs:

No substance-related toxicological findings.

Body weight:

The body weight gain of the animals was not affected by the administration of the test item.

Gross pathology:

No substance-related pathological findings.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

None of the animals died after a single oral administration of 2000 mg/kg bw.
The LD50 (oral, rat) is> 2.000 mg/kg bw.
Clinical symptoms were not observed during the course of investigation.
The body weight gain of the animals was not affected.
No pathological findings were observed.

Executive summary:

The LD50 (oral, rat) is> 2.000 mg/kg bw.