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Diss Factsheets
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EC number: 203-894-2 | CAS number: 111-67-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant, guideline study, available as unpublished report, acceptable with restrictions
- Justification for type of information:
- Read-across between the target substance Oct-2-ene (EC 203-894-2 / CAS 111-67-1) and source substance 1-Decene (EC 212-819-2/ CAS 872-05-9) is based upon the similarity of the chemical structures and their respective physico-chemical properties. The ECHA Read-Across Assessment Framework (RAAF) states that substances with qualitatively similar properties can form the basis of read-across in circumstances where the source and target substances share such similar characteristics.
Target substance Oct-2-ene and source substance 1-Decene are each mono-constituent linear olefins. Structurally, the differences between source and target substances include: 1) the length of the carbon chain (eight for the target substance, and ten for the source substance); and 2) the location of the carbon-carbon double bond (uniformly at the C2 position for the target substance, but uniformly at the C1 terminal position for the source substance).
The target and source substances both fit within the boundaries of chemical category of higher olefins. Studies conducted by the HOPA consortium on a large range of higher olefin category members (including 1-Decene) demonstrated sufficiently similar physico-chemical, environmental fate and toxicological properties to substantiate the basis for read-across; category members in the C6-C10 range may be moderately toxic to highly toxic to aquatic organisms and environmental toxicity is expected to be manifested as non-polar narcosis. Therefore Oct-2-ene (which falls within the C6-C10 range) is expected to behave similarly. Justification for inclusion of Oct-2-ene within the boundaries of the higher olefins category, and the relevance of each category member as an analogue substance to Oct-2-ene, is provided in Section 13 (Document name: “HOPA Higher Olefins CJD with Category Matrix Report [rev 1 Sept 2016]”; Document name: "ACC Product Stewardship Summary for Higher Olefins Category (2008-12-03)”). - Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- Daily renewal of test media with on off analysis
- Vehicle:
- yes
- Details on test solutions:
- A concentrated 10 mg/ml stock solution of dec-1-ene was made by adding 100mg in 10 ml DMF.
The required amount of the stock solution was then added to dechlorinated water and stirred for 48 hours in airtight sealed vessels with the minimum headspace to give the required exposure concentrations. DWC and solvent control test solutions were also be stirred for 48 hours. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- <24 hours old at the start of the test, and not first brood progeny, derived from continuous laboratory cultures. The temperature and dilution water used for culturing the D. magna will be the same as used for the test.
- Test type:
- other: daily renewal
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Salinity:
- not applicable
- Nominal and measured concentrations:
- Nominal concentrations of 0.056, 0.10, 0.18, 0.32, 0.56, 1 and 1.8 mg/l.
Mean measured concentrations of- Details on test conditions:
- Test vessels were glass bottles of 50 ml nominal capacity, filled completely (approximately 60 ml of test solution), with airtight, Teflon faced disc/crimp closures. Elendt M4 test media used. Photoperiod will be controlled to provide 16 hours light: 8 hours dark, with a 20 minute dawn:dusk transition period.Twenty (4 replicates of 5) organisms will be tested for each test concentration.
- Reference substance (positive control):
- no
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.56 - 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.56 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- No mortality in dilution water control or solvent control
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 48 hour EC50 for Daphnia magna lies between 0.56-1.0 mg/l.
- Executive summary:
The toxicity of dec-1 -ene to Daphnia magna was investigated in an OECD 202 test (Brixham Environmental Laboratories, 2010). Due to the low solubility of the test substance the study used a solvent carrier. The test substance was mixed with the solvent before being added to the dilution water. It was then stirred for 48 hours under sealed conditions to maximise the exposure concentrations. The test was carried out with sealed test vessels and the solutions were renewed daily to minimise the loss of the test substance.
At the lower loading rates (0.056 -0.1mg/l) the measured concentrations were below the limit of detection throughout the test. Only the highest exposure concentration had detectable levels of dec-1 -ene after each 24 hour renewal period. Due to the loss of test compound over time the results are reported based on nominal loading rates. The 48 hour EC50 lies between 0.56 and 1 mg/l and the analytical monitoring indicates that the mean exposure concentration at 1mg/l was below the limit of solubility of dec-1 -ene.
Reference
Description of key information
The key study was a semi-static acute invertebrate toxicity test on the effects of an analog substance on the freshwater invertebrate Daphnia magna following OECD Guideline 202 (Brixham Environmental Laboratories, 2010). The 48-h NOEC was reported as 0.56 mg/L and the 48-h LC50 was reported as > 0.56 mg/L and < 1 mg/L based on nominal concentrations. The key value was represented by the minimum value from the reported range of EC50 values in the key study.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.56 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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