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EC number: 271-985-4 | CAS number: 68648-28-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From November 07, 2017 to November 16, 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Test substance name: linseed oil, ester with pentaerythritol
Batch no.: 16.343.096
Appearance: yellow liquid
Composition :100% UVCB,
Purity 100% as the substance is an UVCB
Homogeneity: homogeneous
Storage Room Temperature (20 ± 5°C), after opening keep under inert gas - Analytical monitoring:
- yes
- Details on sampling:
- At the beginning and at the end of the test
- Vehicle:
- yes
- Details on test solutions:
- The water-accommodated fractions (WAFs) were prepared. As the test substance is a clear liquid with a density lower than water, this was done by mixing the nominal load of 10/ 4.6/ 2.2/ 1/0.46 g/L resp. 10.5/4.8/2.3/1.1/0.48 mL/L test substance (based on a density of 0.95 g/mL determined in LAUS study 17030201G912) with the corresponding amount of dilution water and stirring for 7 d. The lower aqueous phase was used as test solution.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Source: Umweltbundesamt, Berlin
- Strain: Berlin
- Sex: female
- Age of parental stock (mean and range, SD): between 0 and 24 h
- Feeding during test: No
- Food type: unicellular green algae (Desmodesmus subspicatus)
- Medium renewal twice a week
- Photo period: 16/8 h, using neon tubes
- Temperature 20 ± 2 °C - Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
- Hardness:
- CaCO3: 250 mg/L
- Test temperature:
- 20 ± 2 °C
- pH:
- 7.8
- Dissolved oxygen:
- 9.2 mg/L
- Nominal and measured concentrations:
- 460, 1000, 2200, 4600 and 10000 mg/L nominal concentration
18, 28, 32, 43 and 66 mg/L geometric mean measured concentrations - Details on test conditions:
- Treatments: 460, 1000, 2200, 4600 and 10000 mg/L nominal concentration
Temperature: 20.7 – 21.7 °C
Duration: 48 h
Observation times: 24 and 48 h
Medium renewal: none
Test vessels: glass beakers, nominal volume 50 mL, tall shape
Replicates (Treatments) 4 vessels, each containing 20 ± 5 mL test solution and 5 daphnia
Replicates (Blank control) 4 vessels, each containing 20 ± 5 mL dilution water and 5 daphnia - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate K2Cr2O7 (CAS No. 7778-50-9)
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 66 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 66 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- 20 daphnia were exposed to the test substance for the treatment for 48 h in a static test system. The concentrations showed no significant toxicity. None of the animals was immobilised in the blank control. At the beginning and at the end of the test, the content of the test substance in the test solutions was determined using DOC-determination. The correlation of the measured concentrations was weak because of the high loading rates and the limited solubility of the test substance. Therefore, the determination of the biological results was based on the geometric mean of the measured concentrations.
- Results with reference substance (positive control):
- Potassium dichromate K2Cr2O7 (CAS No. 7778-50-9) was used as positive control in study to assure that the test conditions are reliable. For the estimation of the EC50 of the positive control, the fit showed sufficient statistical correspondence of the data with the dose-response-equation.
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the study conditions, the 48 h EC50 in Daphnia magna was determined to be > 66 mg/L (measured).
- Executive summary:
A study was conducted to determine the short-term toxicity of the test substance to Daphnia magna according to OECD Guideline 202 and EU Method C.2, in compliance with GLP. Water-accommodated fractions (WAFs) were prepared for the study. As the test substance was a clear liquid with a density lower than water, this was done by mixing the nominal load of 0.46/2.2/4.6/10 g/L resp. 0.48/1.1/2.3/4.8/10.5 mL/L test substance. Daphnia magna were exposed to a series of concentrations (460, 1000, 2200, 4600 and 10000 mg/L nominal concentration) for 48 h. Total organic carbon (TOC) was measured with a TOC analyser and the test substance was considered stable over the duration of the study. No immobilised animal was reported in the test and control groups. Under the study conditions, the 48 h EC50 in Daphnia magna was determined to be >66 mg/L (measured) (Muckle, 2018).
Reference
Immobility:
Nominal Concentration in g/L |
Immobility 24 hours | Immobility 48 hours | ||||||||
absolute | in % | absolute | in % | |||||||
Blank control | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
0.46 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5 |
2.2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
4.6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Description of key information
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 66 mg/L
Additional information
Linseed oil, ester with pentaerythritol
A study was conducted to determine the short-term toxicity of the test substance to Daphnia magna according to OECD Guideline 202 and EU Method C.2, in compliance with GLP. Water-accommodated fractions (WAFs) were prepared for the study. As the test substance was a clear liquid with a density lower than water, this was done by mixing the nominal load of 0.46/2.2/4.6/10 g/L resp. 0.48/1.1/2.3/4.8/10.5 mL/L test substance. Daphnia magna were exposed to a series of concentrations (460, 1000, 2200, 4600 and 10000 mg/L nominal concentration) for 48 h. Total organic carbon (TOC) was measured with a TOC analyser and the test substance was considered stable over the duration of the study. No immobilised animal was reported in the test and control groups. Under the study conditions, the 48 h EC50 in Daphnia magna was determined to be > 66 mg/L (measured) (Muckle, 2018).
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