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EC number: 640-410-2 | CAS number: 2594-75-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- The source compound Wasox-MMAC2 (mixture of: propan-2-one-O,O'-(methoxymethylsilandiyl)dioxime; propan-2-one-O-(dimethoxymethylsilyl)oxime; propan-2-one-O,O',O''-(methylsilantriyl)trioxime, EC No. 460-110-3) is considered a suitable read across partner for the target substance MAC (CAS 2594-75-4). This read-across is based on the hypothesis that source and target substances have similar toxicological properties because:
- structural similarity of the target and the source substances (the presence or absence of additional functional groups or substituents that could influence the behaviour of a chemical),
- similarity in physico-chemical profile of the source and target substances (rapid decomposition in water under cleavage of the same substance (acetone oxime)).
Both substances are similar in terms of the substitution pattern at the silicon atom (i.e. acetoneoximo and methyl group(s)). Both substances exhibit consequently similar physico-chemical properties (rapid decomposition in water, decomposition upon heating to determine boiling point) and exhibit also similar properties in terms of hydrolysis, resulting in the release of the same decomposition product (here: acetone oxime). - Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- No immobilisation was noted in this test. Immobilisation of contral graup daphnia was 0 % at the end of the test (guideline: maximum of 10 %).
There were no contral daphnia trapped at the water surface. pH and temperature were sufficiently stable thraughout the test period. Dissolved oxygen concentration was always higher than 3 mg/L. - Results with reference substance (positive control):
- - Results with reference substance valid?: Yes, according to OECD guideline 202
- 24h EC50: 1.19 mg / L - Validity criteria fulfilled:
- yes
- Conclusions:
- In an acute toxicity test according to the Directive 92/69/EEC Part C.2 Daphnia magna was exposed to 100 mg WASOX-MMAC2/L. No toxic effect on D. magna was observed.
- Executive summary:
The 48-hr-acute toxicity of WASOX-MMAC2 to Daphnia magna was studied under static conditions in accordance with EU Method C.2 and under GLP. Daphnias were exposed to control, and test chemical at nominal concentration of 100 mg/L for 48-hr in a limit test. Mortality, immobilization and sublethal effects were observed daily. The 48- hour EC50 was above 100 mg/L as no effects could be observed.
Based on the results of this study, WASOX-MMAC2 would not be classified as toxic to Daphnia magna Straus in accordance with the CLP classification system.
This study is classified as acceptable and satisfies the guideline requirements for an acute toxicity study with freshwater invertebrates.
Results Synopsis
Test Organism Age (e.g. 1stinstar): less than 24 hours old
Test Type (Flowthrough, Static, Static Renewal): Static
EC50 > 100 mg/L
NOEC ≥ 100 mg a.i./L
Endpoint(s) Effected: Mortality, immobilisation
Reference
Description of key information
To evaluate the toxicity of Methyl-tris acetonoximo-silane (MAC) to aquatic invertebrates read-across from WASOX-MMAC2 is available.
Under the conditions of the valid study reported by Frenzl (2005), the acute toxicity of WASOX-MMAC2 to the freshwater invertebrates Daphnia magna has been investigated according to EU Method C.2 and gave a 48-hr EC50 of greater than 100 mg/L. Correspondingly, the No Observed Effect Concentration was 100 mg/L. This study showed that there were no toxic effects at highest concentration tested. This information is used in a read-across approach in the assessment of the target substance Methyl-tris acetonoximo-silane (MAC).
Key value for chemical safety assessment
Additional information
The information on WASOX-MMAC2 is used in a read-across approach in the assessment of Methyl-tris acetonoximo-silane (MAC).
For details on the read across justification refer to the read across statement in IUCLID section 13.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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