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EC number: 205-182-7 | CAS number: 135-19-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17.05.2018 - 17.05.2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- 2004
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- >= 1.88 - <= 1.9
- Temp.:
- 20 °C
- pH:
- 8.3
- Details on results:
- Quality criteria
The value of log Pow derived from repeated measurements made under identical conditions and using the same set of reference items should fall within a range of ± 0.1 log units.
Typically, the correlation coefficient r for the relationship between log k and log Pow for a set of test substances is around 0.9, corresponding to an octanol/water partition coefficient of log Pow ± 0.5 log units. - Conclusions:
- The partition coefficient log P of 2-Naphthol was determined to be 1.89 at 20°C using the HPLC-method.
- Executive summary:
The partition coefficient at 20 °C of the test item beta-Naphthol was determined by means of the HPLC method, according to Regulation EC No. 440/2008 method A.8. and OECD Test Guideline 117 (2004) to be:
log POW = 1.89 ± < 0.01
Reference
Preliminary Tests
The preliminary test at room temperature showed, that the octanol solubility of the test item was between 309.3 and 555.3 g/L.
Table: Preliminary test for the octanol solubility
Total amount of test item [g] |
Total volume of added octanol [mL] |
Stirring time at RT [min] |
Remark |
0.1247 |
20 |
35 |
dissolved |
1.4176 |
10 |
85 |
dissolved |
3.0931 |
4115 |
dissolved |
|
5.5531 |
1345 |
not dissolved |
With the estimated water solubility of the test item (0.1 – 1.1 g/L) and the estimated solubility in octanol (309.3 – 555.3 g/L) the partition coefficient log POW can be estimated to be between 2.7 and 3.5.
For the determination of the log POW at this value the HPLC method is recommended and carried out.
Main Test
After the measurements of the retention times tR the log k values of the reference items were plotted as a function of their log POW values. The partition coefficient of the test item was obtained by interpolation of the calculated capacity factor on the calibration graph of the reference items.
Table: Retention time of the dead time marker
|
1strun |
2ndrun |
mean value |
t0(min) |
1.615 |
1.616 |
1.616 |
Table: Retention times of the reference items (1stmeasurement)
reference item |
tR |
k |
log k |
log POW[1] |
Acetanilide |
2.012 |
0.245 |
-0.610 |
1.0 |
4-Methyl benzyl alcohol |
2.145 |
0.328 |
-0.484 |
1.6 |
Cinnamyl alcohol |
2.167 |
0.341 |
-0.467 |
1.9 |
Allyl phenyl ether |
3.007 |
0.861 |
-0.065 |
2.9 |
Diphenyl ether |
3.851 |
1.384 |
0.141 |
4.2 |
Fluoranthene |
6.626 |
3.102 |
0.492 |
5.1 |
The first measurement and the linear regression of the calibration graph leads to an equation for the log POW.
Table: Retention times of the reference items (2ndmeasurement)
reference item |
tR |
k |
log k |
log POW1 |
Acetanilide |
2.014 |
0.247 |
-0.608 |
1.0 |
4-Methyl benzyl alcohol |
2.147 |
0.329 |
-0.483 |
1.6 |
Cinnamyl alcohol |
2.169 |
0.343 |
-0.465 |
1.9 |
Allyl phenyl ether |
3.007 |
0.861 |
-0.065 |
2.9 |
Diphenyl ether |
3.852 |
1.384 |
0.141 |
4.2 |
Fluoranthene |
6.630 |
3.104 |
0.492 |
5.1 |
The second measurement and the linear regression of the calibration graph leads to an equation for the log POW. With the determined regression coefficients a and b, the log POW of the test item can be calculated for both measurements.
Table: Retention times of the test item
test item |
tR |
k |
log k |
log POW |
POW |
1stmeasurement |
2.247 |
0.391 |
-0.408 |
1.89 |
78.03 |
2ndmeasurement |
2.248 |
0.392 |
-0.407 |
1.89 |
77.54 |
mean value |
1.89 |
77.78 |
|||
standard deviation |
< 0.01 |
0.35 |
According to Regulation EC No. 440/2008 method A.8. and OECD Test Guideline 117 the test item has a partition coefficient at 20 °C of
log POW= 1.89 ± < 0.01
Description of key information
A study was performed to determine the partition coefficient of the test substance 2-naphthol using a HPLC method. The study was performed in compliance with OECD Test Guideline 117 and Regulation EC No. 440/2008 method A.8. It concluded that the partition coefficient log P of 2-naphthol at 20 oC was 1.89.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.89
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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