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EC number: 260-086-2 | CAS number: 56271-94-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- IN accordance with standard draize methodology but conducted before OECD test guidelines and GLP were introduced
- GLP compliance:
- no
- Remarks:
- Study conducted before GLP was introduced
Test material
- Reference substance name:
- [6R-[6α,7β(Z)]]-7-[2-furyl(methoxyimino)acetamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- EC Number:
- 260-086-2
- EC Name:
- [6R-[6α,7β(Z)]]-7-[2-furyl(methoxyimino)acetamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- Cas Number:
- 56271-94-4
- Molecular formula:
- C15H15N3O7S
- IUPAC Name:
- [6R-[6α,7β(Z)]]-7-[2-furyl(methoxyimino)acetamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- none given
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Albino rabbits of approximatley 2 kg were used.
No other information on husbandry or environmental conditions is available.
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 100mg
- Duration of treatment / exposure:
- 1 hr
- Observation period (in vivo):
- 7 days or as long as injury persists
- Number of animals or in vitro replicates:
- a minimum of three animals
- Details on study design:
- The day before the application of test material the eyes are stained with one
drop of a 5% aqueous solution of sodium fluorescein. The stain
is washed out of the eye after 10 seconds and the cornea is then
examined for existing lesions. Any rabbit showing an abnormality
is discarded.
The test material {l00mg or 0.lml) is instilled into the
lower lid of one eye, and then both lids are held together for a
few seconds. The rabbit is restrained in stocks for the next hour.
The eyes are examined and the degree of irritation assessed
1, 24 and 72 hours, and 7 days after application, or as long as
injury persists, by comparison of the test eye with the control
untreated eye. Fluorescein is applied after land 24 hours, but
at subsequent examinations only when an opacity was present on
the previous occasion. The grading of the irritation is based on
modifications of the method of Draize et al (!) and takes account
of the degree of oedema and redness of the bulbar and palpebral
conjunctivae, the quantity of any discharge, the reaction of the
iris to a light source, and the density and area of any opacity of
the cornea. Each test compound is administered to a minimum of
three rabbits.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: qualitative description
- Basis:
- other: qualitative description
- Time point:
- other: maximum of 7 days
- Reversibility:
- fully reversible
- Remarks on result:
- probability of weak irritation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The conclusion of the study was negligible irritation, having effects on the conjunctiva only.
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