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EC number: 686-853-5 | CAS number: 46921-17-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 6th March 2017 - 24th November 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- GLP, Guidelines : OECD 301 F, NF EN ISO 10304-1
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 4,4-dimethyl-2-undecyl-4,5-dihydro-1,3-oxazole
- EC Number:
- 686-853-5
- Cas Number:
- 46921-17-9
- Molecular formula:
- C16H31NO
- IUPAC Name:
- 4,4-dimethyl-2-undecyl-4,5-dihydro-1,3-oxazole
- Reference substance name:
- Unknown impurities
- IUPAC Name:
- Unknown impurities
- Reference substance name:
- IUPAC name not applicable
- Molecular formula:
- C16H33NO2
- IUPAC Name:
- IUPAC name not applicable
- Reference substance name:
- IUPAC name not applicable
- Molecular formula:
- C28H55NO3
- IUPAC Name:
- IUPAC name not applicable
- Test material form:
- liquid
Constituent 1
impurity 1
impurity 2
impurity 3
- Specific details on test material used for the study:
- Purity : 88,0%
Storage conditions : Room temperature, away from light.
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- Activated sludge were sampled in a wastewater treatment plant. Activated sludge were maintained in the laboratory under aeration condition before use. The concentration of suspended matters of the sludge used for the study was 3,62 g/L.
- Duration of test (contact time):
- ca. 28 d
Initial test substance concentration
- Initial conc.:
- ca. 2 722 other: mg O2/g
- Based on:
- ThOD
- Remarks:
- Test item ThODNO3 (Theoretical Oxygen Demand, with nitrification): 2722 mg O2 / g. Reference item ThOD (Theoretical Oxygen Demand): 1661 mg O2 / g
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- A known quantity of test item was mixed with mineral test media and activated sludge. The preparation was agitated for 28 days in closed vessels containing CO2 trap. O2 uptake was calculated from measure of pressure in the closed vessels. Biodegradation rate was calculated from pressure measurements. Stock solutions were kept approximately at 4°C (refrigerator) without precipitate and were thus suitable to be used for the media preparation.
Test media was ventilated until a value close to saturation in air and pH stabilization (7.55 (criterion 7.4 ± 0.2) were obtained. Test media was kept 1 week for using at room temperature.
Seven bottles (610 mL) were simultaneous prepared as described below in order to have a final volume of solution (252 mL ± 1mL):
- 2 with test media and inoculum (blank solutions = control),
- 2 with test media, inoculum and test item (test item suspensions),
- 1 with test media, inoculum and reference item (reference suspension / procedure control),
- 1 with test media, inoculum, test item and reference item (toxicity control),
- 1 with test media, test item and sterilizing agent (abiotic sterile control).
Each bottle contained a CO2 trap by addition of NaOH pellets. The oxygen consumption was determined by manometry, determining the reduction of pressure in the tests flasks. The bottles were closed off with a system to measure head pressure and were stirred throughout the ready biodegradability test using a magnetic stirrer.
The test was carried out in a laboratory controlled room at 21°C +/- 1°C in the dark (temperature results were recorded on the sheet IM-0033). The BOD (Biological Oxygen Demand) values were given by OXITOP OC 110 Controller and depending from the initial parameters (volume of bottle: 610 mL, filling volume (252 mL ± 1 mL)).
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
% Degradation
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- >= 88 - <= 93
- St. dev.:
- 5.4
- Sampling time:
- 28 d
- Remarks on result:
- other: corrected with NO3 measurement
- Remarks:
- % of biodegradability at 28 days is corrected with NO3 measurement
- Details on results:
- Lag phase was detected between 2 and 4 days.
Percentage of biodegradation at 28 days was 88 and 93 %
60% biodegradation was achieved between 8 and 10 days (lag phase substracted).
10-d window was respected.
Validity:
- Reference control achieved the threshold level (60% of biodegradation) in 2 days (less than 14 days)
- Absolute deviation between two replicates of the test item was 5.4% after 28 days (less than 20%)
- Oxygen uptake of the control was approximately maximum at 13.3 mg/L in 28 days (less than 60 mg/L)
- pH values were in the range 7.-8.5
- Toxicity control showed a biodegradation rate greater than 25% occurred within 14 days, thus the test substance can be assumed to be not inhibitory.
Any other information on results incl. tables
|
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- Ready biodegradability test of lauryl oxazoline by measurement of manometric respirometry over a 28-day period fulfils the requirements of OECD test No. 301F and concludes that this molecule is readily biodegradable.
- Executive summary:
Objective:The scope of this study was, in compliance with the principles of Good Laboratory Pratices (GLP), to determine the ready biodegradability of lauryl oxazoline by measurement of manometric respirometry over a 28-day period.
Method summary: A known quantity of test item was mixed with mineral test media and activated sludge. The preparation was agitated for 28 days in closed vessels containing CO2 trap. O2 uptake was calculated from measure of pressure in the closed vessels. Biodegradation rate was calculated from pressure measurements.
Results:
Lauryl Oxazoline Percentage of biodegradation at 28 days
88 - 93 %
Conclusion
Readily Biodegradable
Ready biodegradability test of lauryl oxazoline by measurement of manometric respirometry over a 28-day period fulfils the requirements of OECD test No. 301F and concludes that this molecule is readily biodegradable.
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