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EC number: 947-979-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10-14 September 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Good quality study under GLP with certificate of analysis, however no chemical analyses. Therefore all concentrations in this report are nominal.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- yes
- Remarks:
- no chemical analyses
- Principles of method if other than guideline:
- no chemical analyses
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Details on sampling:
- no chemical analyses
- Details on test solutions:
- Direct dispersion in water. 2.0 g of test material was dispersed in 1 litre of water to give a 2000 mg/l stock solution. 10 ml, 18 ml,
32 ml, 56 ml and 100 ml of this stock solution were dispersed in 20 litres of diluent to give the test series.
The test material was suspected to absorb to glassware and so saturation of the absorption sites was achieved by soaking the test vessels
overnight prior to the start of the test with the test solutions. At 0 hours the test vessels were emptied, rinsed with the solution to be tested and then refilled with the fresh solution.
Stability of the test concnetrations was ensured by daily renewel of test media. - Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- Rainbow trout (Oncorhynchus mykiss)
Source: Parkwood trout farm, Wigmore, kent, United Kingdom.
The stock of fish was held since 16 July 1991 and was acclimatised to test conditions from 2 September 1991.
The stock fish were maintained in a glass fibre tank with a single-pass water renewal system at 14ºC. The light was controlled to give a 16h light and 8h darkness cycle. Fish were fed dailey with commercial trout pellets, but feeding was discontinued at least 17 hours prior to the test.
Mean standard length = 4.9 cm (SD = 0.3 cm), mean weight = 1.55 mg (SD = 0.26 g), no data on age of fish. - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Post exposure observation period:
- no
- Hardness:
- approximately 50 mg/L as CaCO3
- Test temperature:
- 14.0 ºC
- pH:
- 7.3-7.4
- Dissolved oxygen:
- 10.0 - 10.1 mg O2/L
- Salinity:
- no data
- Nominal and measured concentrations:
- nominal concentartions: 1.0, 1.8, 3.2, 5.6 and 10 mg/l.
- Details on test conditions:
- The test material was suspected to absorb to glassware and so saturation of the absorption sites was achieved by soaking the test vessels overnight prior to the start of the test with the test solutions. At 0 hours the test vessels were emptied, rinsed with the solution to be tested and then refilled
with the fresh test solution.
There was a dailey renewal of test media to ensure stability of the test concentrations.
Test vessels: Glass aquaria holding 20L of test media. 5 test concentration in duplicate, plus 1 control (10 animals per test concentration).
Fish were placed at random in prepared test media, loading 0.78 g bodyweight/L.
Aeration via narrow bore glass tubes.
Temperature: 14ºC
The lightning was controlled at 16h light- 8 h darkness cycle.
Criteria of death: absence of (i) respiratory movement and (ii) response to a physical stimulation. - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 1.8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 2.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95%CL (1.8-3.2 mg/L)
- Results with reference substance (positive control):
- no reference substance tested
- Reported statistics and error estimates:
- 96 h LC50= 2.4 mg/L with 95% Confidence Limit of 1.8-3.2 mg/L
- Sublethal observations / clinical signs:
Nominal concentration (mg/L)
Cumulative Mortality
(initial population: 10)
6 h
24h
48h
72h
96 h
Control
0
0
0
0
0
1.0
0
0
0
0
0
1.8
0
0
0
0
0
3.2
0
0
3
10
10
5.6
0
10
10
10
10
10
10
10
10
10
10
- Validity criteria fulfilled:
- yes
- Conclusions:
- Good quality study, however no chemical analyses therefore concentrations nominal.
- Executive summary:
STUDY SPONSOR: Berol Nobel Nacka AB
PROJECT NUMBER: 116/96
TEST MATERIAL: Ampholak XO7
TEST SPECIES: Rainbow trout (Oncorhynchus mykiss)
TEST TYPE: Acute toxicity 96 h LC50
TEST CONDITIONS: Semi-static test conditions accordi ng to OECD Guideline No. 203 referenced as Method C.1 of Commission Directive 84/449/EEC (which constitutes Annex V of Council Directive 67/584/EEC)
RESULTS:
LC50 (96h) 2.4 mg/L 0.72 mg/L ai
95% condidence limits: 1.8 - 3.2 mg/L 0.54 - 0.96 mg/L ai.
ai = active ingredient
"No Observed Effect Concentration" (NOEC) 1.8 mg/l (0.54 mg ai/l)
Reference
Description of key information
The acute fish study from Handley and Mead (1992) resulted in a 96h LC50 for rainbow trout of 0.72 mg a.i./L based on nominal test concentrations
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.72 mg/L
Additional information
Two acute fish studies with Sodium oleylamphopolycarboxy glycinate are available. Both studies lack the quantification of the test substance during the test. When these studies were performed no suitable sensitive analytical method was available for the quantification of this test substance. The study from Sewell & Grant-Salmon(1993) resulted in a 96h LC50 for rainbow trout of 1.3 mg a.i./L based on nominal test concentrations. The study from Handley and Mead (1992) resulted in a 96h LC50 for rainbow trout of 0.72 mg a.i./L based on nominal test concentrations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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